Publications by authors named "Fabrizio Tedone"
Article Synopsis
- The study investigates how the stroma (connective tissue) surrounding poorly cohesive gastric cancer (PCGC) affects cancer cell adaptation and patient outcomes.
- Researchers classified 75 PCGC specimens as stroma-rich (SR) or stroma-poor (SP) and found that SR tumors are linked to deeper tumor invasion and worse survival rates compared to SP tumors.
- Additionally, mRNA analysis showed that KRT8 levels correlate with tumor behavior, where KRT8-high tumors had better survival outcomes, highlighting the role of stromal content and extracellular proteins in determining tumor aggression and patient prognosis.
Background: Complications can be classified using the most-severe Clavien-Dindo-Classification (CDC) per patient or the total complication burden per patient expressed in the Comprehensive Complication Index (CCI). This study determined the additional value of CCI to CDC in examining the impact of complications after gastric cancer surgery.
Methods: The CCI and CDC were determined in the multicenter randomized LOGICA-trial comparing laparoscopic versus open D2-gastrectomy for cancer (cT1-4aN0-3M0).