Integrative Analysis of Human Macrophage Inflammatory Response Related to Virulence.

(Mtb), the etiological agent of tuberculosis, kills 1.5 to 1.7 million people every year.

Ubiquitination-dependent control of sexual differentiation in fission yeast.

In fission yeast, meiosis-specific transcripts are selectively eliminated during vegetative growth by the combined action of the YTH-family RNA-binding protein Mmi1 and the nuclear exosome. Upon nutritional starvation, the master regulator of meiosis Mei2 inactivates Mmi1, thereby allowing expression of the meiotic program. Here, we show that the E3 ubiquitin ligase subunit Not4/Mot2 of the evolutionarily conserved Ccr4-Not complex, which associates with Mmi1, promotes suppression of meiotic transcripts expression in mitotic cells.