Publications by authors named "Fabrina Hossain"
Background & Aims: There is limited knowledge regarding the longitudinal utility of biomarkers of fibrosis, such as the nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) or the fibrosis-4 score (FIB-4) score. We examined longitudinal changes in the NFS and the FIB-4 score in patients with NAFLD, with and without clinically significant fibrosis (CSF).
Methods: We performed a retrospective study of 230 patients with NAFLD, collecting clinical and laboratory records to calculate NFS and FIB-4 scores at 6 monthly intervals for 5 years before hepatology assessment of fibrosis.
Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], fibrosis 4 score [FIB-4], or enhanced liver fibrosis [ELF] test) are recommended as first-line tools to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease. We aimed to assess the utility of a pragmatic approach to screening for clinically significant fibrosis in primary care and diabetes clinics. We recruited 252 patients from an endocrine clinic or primary care facility.
View Article and Find Full Text PDFAims: To examine the relationship between steatosis quantified by controlled attenuation parameter (CAP) values and glycaemic/metabolic control.
Methods: 230 patients, recruited from an Endocrine clinic or primary care underwent routine Hepatology assessment, with liver stiffness measurements and simultaneous CAP. Multivariable logistic regression was performed to identify potential predictors of Metabolic Syndrome (MetS), HbA1c ≥ 7%, use of insulin, hypertriglyceridaemia and CAP ≥ 300 dB/m.
Alcohol Consumption in Diabetic Patients with Nonalcoholic Fatty Liver Disease.
Can J Gastroenterol Hepatol
August 2018
Article Synopsis
- The study aimed to explore the link between lifetime alcohol consumption and serious liver disease among type 2 diabetes patients with non-alcoholic fatty liver disease (NAFLD).
- It assessed 151 patients, using methods like transient elastography to gauge liver fibrosis, and classified alcohol consumption into nondrinkers, light drinkers, and moderate drinkers.
- The findings indicated that, compared to nondrinkers, light or moderate drinking did not show a significant association with liver fibrosis severity, but highlighted the need for more research on the overall effects of alcohol on liver health and related diabetes issues.
Background: Non-alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners (GP) have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasise the use of fibrosis algorithms or serum biomarkers rather than routine liver tests, to assess advanced fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on diabetic patients with nonalcoholic fatty liver disease (NAFLD), highlighting the prevalence of chronic conditions and medications that complicate their treatment.
- It identifies that a significant portion of these patients experiences multiple health issues, such as metabolic syndrome, depression, and heart disease, with many on several medications.
- Findings reveal that obesity and larger waist size increase the likelihood of having severe liver disease, emphasizing the need for comprehensive healthcare strategies to manage their complex needs.