Publications by authors named "Fabricio Pereira Batista"

Currently available drugs for treatment of glioblastoma, the most aggressive brain tumor, remain inefficient, thus a plethora of natural compounds have already been shown to have antimalignant effects. However, these have not been tested for their impact on tumor cells in their microenvironment-simulated cell models, e.g.

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Article Synopsis
  • Scientists are studying a process called angiogenesis, which is how new blood vessels form from old ones, to help treat conditions where blood flow is reduced.
  • A substance from the bark of a plant called Crataeva tapia (CrataBL) can help support the movement and growth of special cells that form blood vessels.
  • CrataBL has been shown to speed up healing and help with tissue repair in injured mice, suggesting it could be useful for improving blood flow and healing in people too.
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Palythoa caribaeorum is a very common colonial zoanthid in the coastal reefs of Brazil. It is known for its massive production of mucus, which is traditionally used in folk medicine by fishermen in northeastern Brazil. This study identified biologically active compounds in P.

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Cancer progression is associated with an evolving tissue interface of direct epithelial-tumor microenvironment interactions. In biopsies of human breast tumors, extensive alterations in molecular pathways are correlated with cancer staging on both sides of the tumor-stroma interface. These interactions provide a pivotal paracrine signaling to induce malignant phenotype transition, the epithelial-mesenchymal transition (EMT).

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Cell culture is considered the standard media used in research to emulate the in vivo cell environment. Crucial in vivo experiments cannot be conducted in humans and depend on in vitro methodologies such as cell culture systems. However, some procedures involving the quality control of cells in culture have been gradually neglected by failing to acknowledge that primary cells and cell lines change over time in culture.

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