Publications by authors named "Fabricio Freije Garcia"
Article Synopsis
- An efficient enzymatic method was used to create new retinoic acid derivatives, yielding nine compounds, four of which were previously unreported.
- The optimal reaction conditions were explored by testing different variables like enzyme source, solvent, and temperature, enhancing the overall efficiency of the process.
- Some of the new compounds showed lower toxicity than retinoic acid and significantly higher antiviral activity against HSV-1 and HSV-2.
In our search for new safe antiparasitic agents, an enzymatic pathway was applied to synthesize a series of -pyridinylmethyl amides derived from structurally different carboxylic acids. Thirty derivatives, including 11 new compounds, were prepared through lipase-catalyzed acylation in excellent yields. In order to optimize the synthetic methodology, the impact of different reaction parameters was analyzed.
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