Publications by authors named "Fabricio B Pereira"
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood.
View Article and Find Full Text PDFThe relationship between acidosis and coagulopathy has long been described in vitro and in trauma patients, but not yet in orthotopic liver transplantation (OLT). The association of metabolic acidosis with coagulopathy and with transfusion requirements was evaluated in patients submitted to OLT. Changes in acid-base and coagulation parameters were analyzed by repeated measures.
View Article and Find Full Text PDFArticle Synopsis
- * Key immune cells, like monocytes and macrophages, heavily populate the lungs of COVID-19 patients and undergo metabolic changes that support the virus's replication process.
- * The infection boosts mitochondrial ROS production, stabilizing a protein called HIF-1α, which promotes glycolysis and hampers T cell responses, suggesting that targeting HIF-1α could be a promising treatment strategy for COVID-19.
Thalassemia major (TM) patients have altered ventricular volumes and ejection fraction compared to normals, although evidence for these findings stem from restricted patient groups and has never been reproduced. We sought to evaluate cardiac parameters by cardiovascular magnetic resonance (CMR) in a group of young TM patients not covered by previous studies that are more representative of the TM population in many countries. Seventy patients including 40 TM with normal myocardial iron concentrations, and 30 age- and gender-matched normal (NL) volunteers underwent a CMR study for assessment of left and right ventricle volumes and function using a 1.
View Article and Find Full Text PDFObjectives: To assess the level of agreement and interchangeability among different software programs for calculation of T2 values for iron overload.
Methods: T2 images were analysed in 60 patients with thalassaemia major using the truncation method in three software programs. Levels of agreement were assessed using Pearson correlation and Bland-Altman plots.