Publications by authors named "Fabrice V Biot"
Article Synopsis
- The study focuses on the bacteria causing tularemia, which poses a high risk to humans due to its infectious nature, lack of vaccines, and potential use in biological warfare, leading to its classification as a Tier 1 select agent.
- Antibiotic resistance to first-line treatments like fluoroquinolones and aminoglycosides has increased, complicating efforts to manage this disease and prompting the need for new therapeutic developments.
- The researchers created antibiotic-resistant strains of the bacteria to investigate their growth and potential for vaccine development, finding that most ciprofloxacin-resistant strains had reduced virulence in test scenarios, highlighting both resistance and fitness challenges.
(1) Background: is a spore-forming, Gram-positive bacterium causing anthrax, a zoonosis affecting mainly livestock. When occasionally infecting humans, provokes three different clinical forms: cutaneous, digestive and inhalational anthrax. More recently, an injectional anthrax form has been described in intravenous drug users.
View Article and Find Full Text PDFis the causative agent of tularemia and has gained recent interest as it poses a significant biothreat risk. is commonly used as a laboratory surrogate for tularemia research due to genetic similarity and susceptibility of mice to infection. Currently, there is no FDA-approved tularemia vaccine, and identifying therapeutic targets remains a critical gap in strategies for combating this pathogen.
View Article and Find Full Text PDFInhalational anthrax caused by , a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to antibiotics, although no conclusive evidence demonstrates that anthrax antitoxin therapy has any significant benefit. We discuss here the rational basis of anti-PA development regarding the pathogenesis of the disease.
View Article and Find Full Text PDFArticle Synopsis
- Francisella tularensis is a dangerous bacterium that causes tularemia and poses a biowarfare threat due to its low infectious dose and ability to infect multiple mammals, including humans.
- Researchers studied a ciprofloxacin-resistant mutant of this bacterium to understand its genetic changes and characteristics that contribute to antibiotic resistance.
- Key findings include a mutation in the kdsD gene, crucial for lipopolysaccharide production, leading to growth defects and reduced virulence, highlighting kdsD as a potential target for new treatments against tularemia.
Background: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure.
Methodology/principal Findings: We used doxycycline selection to obtain several resistant B.
Burkholderia is a bacterial genus comprising several pathogenic species, including two species highly pathogenic for humans, B. pseudomallei and B. mallei.
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