Publications by authors named "Fabrice Susin"
Article Synopsis
- ASPCR is a cost-effective method for detecting HIV-1 drug resistance mutations, showing potential for use in resource-limited settings.
- In a study involving 44 HIV-1 plasma samples from patients in Chad, ASPCR demonstrated strong correlation with Sanger sequencing for detecting six major drug resistance mutations, with R values over 0.97 and desirable threshold differences for most mutations.
- While ASPCR showed high reproducibility and improved detection rates for multiple mutations, the detection of the K70R mutation was less effective compared to other mutations, highlighting areas for refinement in this diagnostic approach.
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.
Chatté Adawaye Joseph Fokam Erick Kamangu Hamit Mahamat Alio Aoudalkarim Moussa Chahad Fabrice Susin
BMC Res Notes
November 2017
Background: The national antiretroviral therapy in the Republic of Chad provides free of charge antiretroviral regimens and therapeutic monitoring for patients receiving antiretroviral therapy nationwide. For a successful programmatic uptake, these efforts merit to be supported by thorough assessments of antiretroviral therapy response and HIV-1 drug resistance surveillance, especially with risks of cross-resistance due to the gradual stavudine phasing out in such national settings. We therefore evaluated the virological response to antiretroviral therapy, HIV-1 drug resistance emergence and circulating HIV-1 clades in a Chad context.
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