Causes and consequences of tipping points in river delta social-ecological systems.

The sustainability of social-ecological systems within river deltas globally is in question as rapid development and environmental change trigger "negative" or "positive" tipping points depending on actors' perspectives, e.g. regime shift from abundant sediment deposition to sediment shortage, agricultural sustainability to agricultural collapse or shift from rural to urban land use.

Risk assessment for hurricane-induced pluvial flooding in urban areas using a GIS-based multi-criteria approach: A case study of Hurricane Harvey in Houston, USA.

As one of the most destructive nature hazards, hurricane-induced flooding generates serious adverse impacts on populations, infrastructure, and the environment globally. In urban areas, complex characteristics such as high population and infrastructure densities increase flood disaster risks. Consequently, the assessment of flood risks is becoming increasingly important for understanding potential impacts on an urban area and proposing disaster risk mitigation strategies.

Aligning the Global Delta Risk Index with SDG and SFDRR global frameworks to assess risk to socio-ecological systems in river deltas.

Unlabelled: River deltas globally are highly exposed and vulnerable to natural hazards and are often over-exploited landforms. The Global Delta Risk Index (GDRI) was developed to assess multi-hazard risk in river deltas and support decision-making in risk reduction interventions in delta regions. Disasters have significant impacts on the progress towards the Sustainable Development Goals (SDGs).

Risk tolerance as a complementary concept to risk perception of natural hazards: A conceptual review and application.

There is a longstanding assumption that if people perceive a risk as high, they will act to reduce it. In fact, research has shown a lack of consistently strong causal relations between risk perception (RP) and mitigative behavior-the so-called "risk perception paradox." Despite a recent increase in research on RP, individuals' risk tolerance (RT; or demand for risk reduction) only rarely appears as a consideration for explaining behavioral response to natural hazards.

A framework for integrating ecosystem services indicators into vulnerability and risk assessments of deltaic social-ecological systems.

Due to increasing population pressure and urbanization, as well as global climate change impacts, many coastal river deltas are experiencing increased exposure, vulnerability and risks linked to natural hazards. Mapping the vulnerability and risk profiles of deltas is critical for developing preparedness, mitigation and adaptation policies and strategies. Current vulnerability and risk assessments focus predominantly on social factors, and typically, do not systematically incorporate a social-ecological systems perspective, which can lead to incomplete assessments.

Sea level rise risks and societal adaptation benefits in low-lying coastal areas.

Sea level rise (SLR) will increase adaptation needs along low-lying coasts worldwide. Despite centuries of experience with coastal risk, knowledge about the effectiveness and feasibility of societal adaptation on the scale required in a warmer world remains limited. This paper contrasts end-century SLR risks under two warming and two adaptation scenarios, for four coastal settlement archetypes (Urban Atoll Islands, Arctic Communities, Large Tropical Agricultural Deltas, Resource-Rich Cities).

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8 T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function and fate remains elusive. We found that genetic deletion of MPC drives CD8 T cell differentiation toward a memory phenotype.

Green, hybrid, or grey disaster risk reduction measures: What shapes public preferences for nature-based solutions?

Nature-based solutions (NbS) contrast with grey infrastructure measures to reduce risk from natural hazards. Using natural and sustainable measures (green) or combining green with grey elements (hybrid) can provide important co-benefits beyond risk reduction. Thanks to their co-benefits and flexibility across a range of possible climate change futures, NbS are sometimes referred to as 'win-win' or 'no-regret' measures.

Ecosystem services and disservices in the Luanhe River Basin in China under past, current and future land uses: implications for the sustainable development goals.

Unlabelled: Understanding how ecosystem services (ES) and ecosystem disservices (EDS) are affected by human-induced landscape changes is important to minimise trade-offs and maximise synergies between Sustainable Development Goals (SDGs) and targets, and for equitable development across governance scales. However, limited research investigates how ES and EDS can change under past, current, and future land uses. This study, conducted in the Luanhe River Basin (LRB), demonstrates the interaction between humans and the environment under past, current, and future land uses at the river basin scale in China, using a stakeholders' participatory capacity matrix to characterise both ES and EDS.

Modelling land system evolution and dynamics of terrestrial carbon stocks in the Luanhe River Basin, China: a scenario analysis of trade-offs and synergies between sustainable development goals.

Unlabelled: A more holistic understanding of land use and land cover (LULC) will help minimise trade-offs and maximise synergies, and lead to improved future land use management strategies for the attainment of Sustainable Development Goals (SDGs). However, current assessments of future LULC changes rarely focus on the multiple demands for goods and services, which are related to the synergies and trade-offs between SDGs and their targets. In this study, the land system (combinations of land cover and land use intensity) evolution trajectories of the Luanhe River Basin (LRB), China, and major challenges that the LRB may face in 2030, were explored by applying the CLUMondo and InVEST models.

A review of public acceptance of nature-based solutions: The 'why', 'when', and 'how' of success for disaster risk reduction measures.

Nature-based solutions (NbS) are increasingly recognized as sustainable approaches to address societal challenges. Disaster risk reduction (DRR) has benefited by moving away from purely 'grey' infrastructure measures towards NbS. However, this shift also furthers an increasing trend of reliance on public acceptance to plan, implement and manage DRR measures.

Salinity-independent dissipation of antibiotics from flooded tropical soil: a microcosm study.

River deltas are frequently facing salinity intrusion, thus challenging agricultural production in these areas. One adaption strategy to increasing salinity is shrimp production, which however, heavily relies on antibiotic usage. This study was performed to evaluate the effect of increasing salinity on the dissipation rates of antibiotics in tropical flooded soil systems.

Towards an operationalisation of nature-based solutions for natural hazards.

Nature-based solutions (NBS) are being promoted as adaptive measures against predicted increasing hydrometeorological hazards (HMHs), such as heatwaves and floods which have already caused significant loss of life and economic damage across the globe. However, the underpinning factors such as policy framework, end-users' interests and participation for NBS design and operationalisation are yet to be established. We discuss the operationalisation and implementation processes of NBS by means of a novel concept of Open-Air Laboratories (OAL) for its wider acceptance.

Vulnerability and risk of deltaic social-ecological systems exposed to multiple hazards.

Coastal river deltas are hotspots of global change impacts. Sustainable delta futures are increasingly threatened due to rising hazard exposure combined with high vulnerabilities of deltaic social-ecological systems. While the need for integrated multi-hazard approaches has been clearly articulated, studies on vulnerability and risk in deltas either focus on local case studies or single hazards and do not apply a social-ecological systems perspective.

Development and validation of risk profiles of West African rural communities facing multiple natural hazards.

West Africa has been described as a hotspot of climate change. The reliance on rain-fed agriculture by over 65% of the population means that vulnerability to climatic hazards such as droughts, rainstorms and floods will continue. Yet, the vulnerability and risk levels faced by different rural social-ecological systems (SES) affected by multiple hazards are poorly understood.

Population dynamics, delta vulnerability and environmental change: comparison of the Mekong, Ganges-Brahmaputra and Amazon delta regions.

Tropical delta regions are at risk of multiple threats including relative sea level rise and human alterations, making them more and more vulnerable to extreme floods, storms, surges, salinity intrusion, and other hazards which could also increase in magnitude and frequency with a changing climate. Given the environmental vulnerability of tropical deltas, understanding the interlinkages between population dynamics and environmental change in these regions is crucial for ensuring efficient policy planning and progress toward social and ecological sustainability. Here, we provide an overview of population trends and dynamics in the Ganges-Brahmaputra, Mekong and Amazon deltas.

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam.

The Mekong Delta in Vietnam has seen a rapid development and intensification of aquaculture in the last decades, with a corresponding widespread use of antibiotics. This study provides information on current antibiotic use in freshwater aquaculture, as well as on resulting antibiotic concentrations in the aquatic environment of the Mekong Delta. Two major production steps, fish hatcheries and mature fish cultivation, were surveyed (50 fish farm interviews) for antibiotic use.

Interdisciplinary assessment of sea-level rise and climate change impacts on the lower Nile delta, Egypt.

CLImate-induced changes on WAter and SECurity (CLIWASEC) was a cluster of three complementary EC-FP7 projects assessing climate-change impacts throughout the Mediterranean on: hydrological cycles (CLIMB - CLimate-Induced changes on the hydrology of Mediterranean Basins); water security (WASSERMed - Water Availability and Security in Southern EuRope and the Mediterranean) and human security connected with possible hydro-climatic conflicts (CLICO - CLImate change hydro-COnflicts and human security). The Nile delta case study was common between the projects. CLIWASEC created an integrated forum for modelling and monitoring to understand potential impacts across sectors.

Spatial and temporal variability of surface water pollution in the Mekong Delta, Vietnam.

Surface water pollution in the Vietnamese Mekong Delta (MD) could threaten human, animal and ecosystem health given the fact that this water source is intensively used for drinking, irrigation and domestic services. We therefore determined the levels of pollution by organic pollutants, salts, metals and microbial indicators by (bi)monthly monitoring of canals between November 2011 and July 2012 at 32 sampling locations, representing fresh and saline/brackish environments. The results were compared with national water quality guidelines, between the studied regions and with water quality data from main waterways.

Effects of local and spatial conditions on the quality of harvested rainwater in the Mekong Delta, Vietnam.

The objective of this study was to assess the quality of harvested rainwater in the Mekong Delta (MD), Vietnam for local (roof types, storage system and duration) and spatial (proximity of industry, main roads, coastline) conditions. 78 harvested rainwater samples were collected in the MD and analyzed for pH, turbidity, TDS, COD, nutrients (NH4, NO3, NO2, o-PO4), trace metals and coliforms. The results show that thatch roofs lead to an increase of pollutants like COD (max 23.

Pesticide management and their residues in sediments and surface and drinking water in the Mekong Delta, Vietnam.

Public concern in Vietnam is increasing with respect to pesticide pollution of the environment and of drinking water resources. While established monitoring programs in the Mekong Delta (MD) focus on the analysis of organochlorines and some organophosphates, the environmental concentrations of more recently used pesticides such as carbamates, pyrethroides, and triazoles are not monitored. In the present study, household level pesticide use and management was therefore surveyed and combined with a one year environmental monitoring program of thirteen relevant pesticides (buprofezin, butachlor, cypermethrin, α-endosulfan, β-endosulfan, endosulfan-sulfate, fenobucarb, fipronil, isoprothiolane, pretilachlor, profenofos, propanil, and propiconazole) in surface water, soil, and sediment samples.

Pesticide pollution in agricultural areas of Northern Vietnam: case study in Hoang Liet and Minh Dai communes.

Soils and agricultural products from the Red River basin in Northern Vietnam were reported to be contaminated by agrichemicals. To assess potential exposure of local farmers and consumers to these contaminants, pesticide use and management practices of local farmers were surveyed and residue concentrations were determined for recently used as well as for banned pesticides in water, soil, vegetables, and fish samples in two communes of Northern Vietnam. DDTs, HCHs, and Drin compounds still persist at relatively high concentrations in soil and occur in vegetable and fish samples.

Simulating pesticides in ditches to assess ecological risk (SPIDER): II. Benchmarking for the drainage model.

SPIDER (simulating pesticides in ditches to assess ecological risk) is a locally distributed, capacitance-based model that accounts for pesticide entry into surface water bodies via spray drift, surface runoff, interlayer flow and drainage. SPIDER was developed for application to small agricultural catchments. Transport of pesticide from site of application to surface water via subsurface field drains is one of the major routes of entry to surface water.

Simulating pesticides in ditches to assess ecological risk (SPIDER): I. Model description.

Risk assessment for pesticides in the aquatic environment relies on a comparison between estimated exposure concentrations in surface water bodies and endpoints from a series of effect tests. Many field- and catchment-scale models have been developed, ranging from simple empirical models to comprehensive, physically-based, distributed models that require complex parameterisation, often through inverse modelling methods. Routine use of catchment models for assessment and management of pesticides requires a tool that is comprehensive in being able to address all major routes of entry of pesticides into surface water and that has reasonable parameter requirements.

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

The Aurora kinases have been the subject of considerable interest as targets for the development of new anticancer agents. While evidence suggests inhibition of Aurora B kinase gives rise to the more pronounced antiproliferative phenotype, the most clinically advanced agents reported to date typically inhibit both Aurora A and B. We have discovered a series of pyrazoloquinazolines, some of which show greater than 1000-fold selectivity for Aurora B over Aurora A kinase activity, in recombinant enzyme assays.