Three New Polyphenol Derivatives from the Fruits of Macaranga Monandra and their Antioxidant Potential.

Phytochemical investigation of the methanol extract from the fruits of Macaranga monandra (Euphorbiaceae Muell. et Arg.) afforded one new geranylated 1',2'-dihydrophenanthrene and two new flavonoid derivatives, named macamondrin (1), macamondrione A (2) and B (3) respectively.

In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two cameroonian medicinal plants.

Background: Treatment of Candida infections have become increasingly difficult due to antifungal drug resistance, which has drawn attention toward the search for innovative and effective drugs. This study aimed to assess the activity of essential oils (EOs) from Pentadiplandra brazzeana Baillon (PB) root and Drypetes gossweileri S. Moore (DG) stem bark against Candida albicans and Candida parapsilopsis strains, and determine their antifungal mechanism when tested alone or combined.

Constituents of the Stem Bark of Linn. f. with Antileishmanial and Antibacterial Activities.

The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (), V ()/W (), and a new tocotrienol derivative named globuliferanol (), along with 11 known compounds (-).

Anti-inflammatory, Antinociceptive, and Toxicological Properties of Stem Crude Extract and Fractions.

The present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity , red blood cell lysis inhibition assay and albumin denaturation inhibition were performed, while measurements of carrageenan-induced paw oedema and formalin-induced pain in albino mice were performed.

Two new secondary metabolites with antibacterial activities from (Asteraceae).

The bio guided fractionation of the dichloromethane/methanol (1:1) crude extract of the air-dried whole plant of led to the isolation of one new flavone derivative designated conyflavone () and one new clerodane diterpene type designated conyclerodane () along with five known compounds including two flavonoids Gardenin C (), chrysosplenetin () and two steroids glucoside of -sitosterol (), the mixture of stigmasterol () and -sitosterol () and ent-2b,18,19trihydroxycleroda-3,13-dien-16,15-olide (). The structures were established by spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectroscopy and by comparison to data of related compounds described in literature. The stereocentres in compound 2 were determined by SC-XRD analysis.

Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity.

Ripe figs, barks, and wood of Ficus vallis-choudae are used in traditional medicine against several conditions including nausea and malaria. However, its use is still to be scientifically documented and validated. Hence, the aim of the present work was to evaluate the antiplasmodial activity of the dichloromethane-methanol (DCM-MeOH (1:1)) crude extract, their hexane, dichloromethane, ethyl acetate, and methanoli fractions, as well as the isolated chemical constituents.

In vitro and in vivo antiplasmodial activity of hydroethanolic bark extract of Bridelia atroviridis müll. Arg. (Euphorbiaceae) and lc-ms-based phytochemical analysis.

Ethnopharmacological Relevance: Malaria is a life-threatening health problem worldwide and treatment remains a major challenge. Natural products from medicinal plants are credible sources for better anti-malarial drugs.

Aim Of The Study: This study aimed at assessing the in vitro and in vivo antiplasmodial activities of the hydroethanolic extract of Bridelia atroviridis bark.

Endophytic bacteria of desert cactus (Euphorbia trigonas Mill) confer drought tolerance and induce growth promotion in tomato (Solanum lycopersicum L.).

Endophytic bacteria isolated from cactus were characterized and assessed for their capability to induce drought tolerance and growth promotion in tomato. A total of 191-bacteria representing 13-genera and 18-species were isolated from wild cactus, Euphorbia trigonas. Bacillus (58), Lysinibacillus (36), Enterobacter (29), Stenotrophomonas (18), Lelliottia (12) and Pseudomonas (12) were the most represented genera.

Constituents from with Anti- Type b Inhibitory Activities.

Three previously undescribed indole alkaloids, named latifolianine A () and latifoliaindoles A and B ( and ), along with 10 known compounds (-), were isolated from the heartwood of . Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A () represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety.

Two new flavones glycosides with antimicrobial activities from Gürke (Lamiaceae).

Gürke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a () and clerodendronone 1b () along with two known compounds: 5,7-dihydroxy-4'-methoxyflavone () and 5-hydroxy-7,4'-dimethoxyflavone (). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information.

Hydroethanolic Extracts of and Reduced Parasitemia in Balb/c Mice.

Malaria is one of the most important infectious diseases in Africa especially in Cameroon. The nonaccessibility to current treatments for poor people and the appearance of drug-resistant parasites stimulate the search for alternative treatments. The aim of this study was to evaluate the antimalarial activity and the safety of hydroethanolic extracts from and .

Cameroonian medicinal plants belonging to Annonaceae family: radical scavenging and antifungal activities.

The free-radical scavenging activity of ethanolic and methanolic extracts of leaves, stems and roots of Annona muricata, Monodora tenuifolia, Uvaria comperei, Uvaria muricata and Xylopia africana was evaluated using DPPH and ORAC assays. Further, phytochemical analysis, total phenolic and total flavonoid contents were also determined. Moreover, the antifungal activity of extracts was studied.

Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana.

Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids N(a)-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC(50) 2.