Publications by authors named "Fabiola Galiana-Melendez"
Article Synopsis
- - Demyelination involves the loss of myelin sheath and oligodendrocytes, leading to damaged axons, brain atrophy, and neuronal degeneration due to neuroinflammation and cell death.
- - The study uses a cuprizone mouse model to explore the effects of non-invasive gamma stimulation through sensory input as a treatment method for promoting myelination and reducing inflammation.
- - Results indicate that multisensory gamma stimulation can reduce demyelination, promote the formation of oligodendrocytes, maintain neuronal function, and lessen brain inflammation, highlighting its potential as a therapy for demyelinating diseases.
Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways that underlie its pathological progression across brain regions remain poorly understood. Here we report a single-cell transcriptomic atlas of six different brain regions in the aged human brain, covering 1.3 million cells from 283 post-mortem human brain samples across 48 individuals with and without Alzheimer's disease.
View Article and Find Full Text PDFPurpose Of Review: The purpose of this review is to discuss the musculoskeletal consequences of cancer, including those that occur in the absence of bone metastases.
Recent Findings: Cancer patients frequently develop cachexia, a debilitating condition reflected by weight loss and skeletal muscle wasting. The negative effects that tumors exert on bone health represents a growing interest amongst cachexia researchers.
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes that occur in specific cell types have not been fully characterized. Here, we profile single-nucleus transcriptomes in the human cerebrovasculature in six brain regions from 220 individuals with AD and 208 age-matched controls. We annotate 22,514 cerebrovascular cells, including 11 subtypes of endothelial, pericyte, smooth muscle, perivascular fibroblast and ependymal cells.
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