Accuracy of Doppler assessment of the uterine arteries in healthy girls for the diagnosis of pubertal onset.

Purpose: To evaluate the accuracy of the uterine artery pulsatility index (PI) for the diagnosis of pubertal onset in girls.

Methods: Cross-sectional study of girls with normal pubertal development. Puberty was diagnosed by the presence of Tanner breast development score ≥2.

Non-alcoholic fatty liver disease (Nafld) in obese children- effect of refined carbohydrates in diet.

Background: The incidence of childhood obesity has increased progressively and, associated with this, nonalcoholic fatty liver disease (NAFLD) has often been diagnosed in this age group. To determine the risk factors associated with NAFLD in obese children, with special emphasis on diet.

Methods: A prospective cross-sectional study was conducted with obese children referred to the endocrinology outpatient clinic.

Role of ambulatory blood pressure monitoring in patients with acromegaly.

Background: Hypertension is associated with increased cardiovascular deaths in patients with acromegaly.

Objective: To evaluate the accuracy of blood pressure (BP) by 24-h ambulatory blood pressure monitoring (ABPM) and office BP measurements to represent the real BP status in acromegalic patients and its relationship with acromegalic activity and echocardiogram parameters.

Patients And Methods: Cohort of 37 patients with acromegaly in a tertiary endocrine outpatient service.

A successful case of Cushing's disease pregnancy treated with ketoconazole.

Purpose: The association of pregnancy and Cushing's disease (CD) is rare. Treatment of Cushing's syndrome (CS) is imperative to reduce maternal and fetal morbidity. Ketoconazole is a widely used drug for CS control when the woman is not pregnant but concerns about its teratogenicity and embryotoxicity restricted its use during pregnancy.

Evaluation of the DDAVP test in the diagnosis of Cushing's Disease.

Objective: To analyse the performance of the desmopressin (DDAVP) test in the diagnosis of Cushing's disease (CD).

Methods: This was a prospective cohort study of 124 patients with suspected hypercortisolism who were recruited from an outpatient endocrinology clinic and investigated for Cushing's syndrome (CS). The ACTH and cortisol responses to the DDAVP test were assessed to determine patient diagnosis and test the procedure's diagnostic accuracy.

Evaluation of Cushing's disease remission after transsphenoidal surgery based on early serum cortisol dynamics.

Objective: To evaluate the ability of post-transsphenoidal pituitary surgery (TSS) serum cortisol levels (s-cortisol) to predict surgical remission and recurrence of Cushing's disease (CD).

Design: One hundred and three patients with CD from a tertiary referral centre were prospectively analysed over 6·0 ± 4·8 years of follow-up. Twenty patients received perioperative glucocorticoids as routine care and had s-cortisol measured 10-12 days after TSS (Protocol I).

[Assessment of the hypothalamic-pituitary-adrenal axis in Cushing's disease diagnosis and remission].

Cushing's disease (CD) remains a medical challenge, with many questions still unanswered. Successful treatment of CD patients is closely related to correct approach to syndromic and etiological diagnosis, besides the experience and talent of the neurosurgeon. Pituitary transsphenoidal adenomectomy is the treatment of choice for DC.

Diabetes mellitus in a cohort of patients with acromegaly.

Objectives: To evaluate the presence of diabetes mellitus (DM) in a cohort of patients with acromegaly.

Methods: This was a cross sectional study.

Results: Fifty-eight acromegalic patients were assessed.

Hypertension-related factors in patients with active and inactive acromegaly.

Introduction: There are several complications of the cardiovascular system caused by acromegaly, especially hypertension.

Objectives: To evaluate hypertension characteristics in patients with cured/controlled acromegaly and with the active disease.

Patients And Methods: Cross-sectional study of the follow-up of forty-four patients with acromegaly submitted to clinical evaluation, laboratory tests and cardiac ultrasound.

Pseudotumor cerebri during Cushing's disease treatment with ketoconazole.

Benign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracranial hypertension during treatment with ketoconazole.

Combined 17α-hydroxylase/17,20-lyase deficiency due to p.R96W mutation in the CYP17 gene in a Brazilian patient.

Congenital adrenal hyperplasia (CAH) resulting from 17α-hydroxylase/17,20-lyase deficiency is a rare autosomal recessive disease and the second most common form of CAH in Brazil. We describe the case of a Brazilian patient with CYP17 deficiency (17α-hydroxylase/17,20-lyase deficiency) caused by a homozygous p.R96W mutation on exon 1 of the CYP17 gene, an unusual genotype in Brazilian patients with this form of CAH.