Publications by authors named "Fabiola Blasco-Hernando"
Article Synopsis
- HIV infection causes chronic inflammation, leading to accelerated aging and comorbidities, even with effective antiretroviral treatments (ART).
- This study analyzed circulating microRNAs (miRNAs) in treatment-naïve HIV patients and found significant differences in miRNA levels compared to uninfected individuals, which persisted after one year on ART.
- Results showed elevated miR-21-5p and reduced levels of miR-6503-3p and miR-3135b in HIV patients, suggesting a connection between these miRNAs and inflammation/immune response, particularly with miR-21-5p indicating ongoing issues with inflammation and oxidative stress.
The objective was to compare clinical characteristics, outcomes, and economic differences in complicated urinary tract infections (cUTI) caused by extensively drug-resistant Pseudomonas aeruginosa (XDR P. aeruginosa) and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-K. pneumoniae).
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- Long-term non-progressors (LTNPs) are HIV+ individuals whose viral replication is controlled but still face complications like bone remodeling impairment.
- A study measured bone strength components and inflammatory biomarkers among LTNPs, HIV+ progressors, and HIV-negative individuals, revealing that LTNPs had lower bone material strength (BMSi) and a distinct inflammatory profile.
- The findings indicate that LTNPs experience worse bone tissue quality compared to both HIV+ progressors and HIV-negative individuals, suggesting a broader impact of HIV infection on bone health.
One of the hallmarks of SARS-CoV-2 infection is an induced immune dysregulation, in some cases resulting in cytokine storm syndrome and acute respiratory distress syndrome (ARDS). Several physiological parameters are altered as a result of infection and cytokine storm. Among them, microRNAs (miRNAs) might reflect this poor condition since they play a significant role in immune cellular performance including inflammatory responses.
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- The study investigates neurocognitive impairment (NI) and frailty in older adults living with HIV, focusing on risk factors associated with these conditions.
- Conducted with 40 HIV-positive individuals aged over 65 in Barcelona, it used clinical assessments and blood testing to measure NI and frailty.
- Results revealed that low education level, a nadir CD4+ T-cell count below 350 cells/mm, and the presence of comorbidities (especially diabetes) significantly increased the risk of neurocognitive disorders in this population.
Unlabelled: Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 infection.
Methods: Cohort observational study with consecutive older-adults (≥65 years old), with confirmed SARS-CoV-2 infection admitted to a university hospital between March-May 2020.