Publications by authors named "Fabiola A Leite"
Pediatr Blood Cancer
November 2014
Article Synopsis
- - The study investigates the expression of three HLA class II genes (HLA-DRA, HLA-DPA1, and HLA-DPB1) in pediatric adrenocortical tumors (ACT) to determine their impact on disease aggressiveness and patient prognosis.
- - Results show that lower expression levels of these genes are linked to worse outcomes, including older age at diagnosis, larger tumor size, and a higher likelihood of metastatic disease, with HLA-DPA1 identified as a significant independent prognostic factor.
- - The findings suggest that decreased expression of these genes, particularly HLA-DPA1, may indicate a more aggressive disease course in pediatric ACT, which could serve as a potential marker for tumor aggressiveness. *
