Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease.

Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients.

[Influence of circadian and temperature variations on the ischemic stroke].

Background: Ischemic stroke (IS) ranks third as cause of death and annual costs. Literature shows a greater number of cases in the first hours of the morning and on colder days, allowing for better prevention at these times. The objectives were to identify risk factors, evaluate the influence of circadian and temperature variations on prevalence of IS.