Publications by authors named "Fabio de Carne"

Introduction: We aim to critically assess Microultrasound (mUS) clinical performance in an outpatient setting, focusing on its ability to reduce unnecessary diagnostic procedures, potentially reshape prostate cancer (PCa) diagnostic protocols, and increase the ability to rule out clinically significant (Gleason Score ≥ 3 + 4) PCa (csPCa).

Materials And Methods: Between November 2018 and April 2022, we conducted a prospective study involving men who underwent mUS examination due to clinical symptoms, PSA elevation, or opportunistic early detection of PCa. Experienced urologists performed mUS assessments in an outpatient setting using the prostate risk identification using micro-ultrasound (PRI-MUS) protocol to identify lesions suspicious of csPCa (PRI-MUS score ≥ 3).

View Article and Find Full Text PDF

Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases.

Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa).

View Article and Find Full Text PDF

Objectives: To develop a microultrasound-based nomogram including clinicopathological parameters and microultrasound findings to predict the presence of extra-prostatic extension and guide the grade of nerve-sparing.

Material And Methods: All patients underwent microultrasound the day before robot-assisted radical prostatectomy. Variables significantly associated with extra-prostatic extension at univariable analysis were used to build the multivariable logistic model, and the regression coefficients were used to develop the nomogram.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists wanted to see how well two types of prostate cancer tests worked for men who had suspicious signs during exams and scans.
  • They found that using microultrasound-targeted biopsy (microUSTBx) with systematic biopsy (SBx) found cancer just as well as another method called mpMRI with targeted biopsy (MTBx).
  • This new method not only helped find cancer accurately but also prevented many unnecessary tests, making it a better choice for some patients.
View Article and Find Full Text PDF
Article Synopsis
  • Active surveillance (AS) is a common approach for managing low-risk prostate cancer, but identifying candidates for AS is difficult; this study investigates the effectiveness of microultrasound (microUS) in conjunction with mpMRI for monitoring these patients.
  • A total of 100 prostate cancer patients underwent TRUS with microUS and targeted biopsies, revealing that 34 patients were upgraded to more significant disease at confirmatory biopsies, highlighting microUS's role in identifying clinically relevant cancer.
  • The findings indicate that both microUS and mpMRI are highly sensitive tools for detecting clinically significant prostate cancer, which could improve decision-making in the management of patients undergoing active surveillance.
View Article and Find Full Text PDF

Background: Multiparametric magnetic resonance imaging (mpMRI) is an invaluable diagnostic tool in the decision-making for prostate biopsies (PBx). However, a non-negligible proportion of patients with negative MRI (nMRI) may still harbour prostate cancer (PCa).

Objective: To assess whether microultrasound (micro-US) can help in substratifying the presence of PCa and clinically significant PCa (csPCa; ie, any Gleason score ≥7 PCa) in patients with nMRI despite a persistently high clinical suspicion of PCa.

View Article and Find Full Text PDF