Publications by authors named "Fabio Varon"

Article Synopsis
  • Tigecycline is a new class of antibiotics approved for specific infections, but it is often used off-label, particularly for ventilator-associated pneumonia (VAP).
  • In a study analyzing 209 patients across Latin America, 68.5% received tigecycline for off-label use, with 47% of those having some scientific support for their indications.
  • The most common pathogens identified were multi-drug resistant Acinetobacter spp., and despite a 69% success rate, the overall mortality was high at 35.5%, highlighting the need for careful consideration of tigecycline's use in such cases.
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Community-acquired pneumonia (CAP) in adults is probably one of the infections affecting ambulatory patients for which the highest diversity of guidelines has been written worldwide. Most of them agree in that antimicrobial therapy should be initially tailored according to either the severity of the infection or the presence of comorbidities and the etiologic pathogen. Nevertheless, a great variability may be noted among the different countries in the selection of the primary choice in the antimicrobial agents, even for the cases considered as at a low-risk class.

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