Publications by authors named "Fabio Santos Lira"

The objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12-week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T test.

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Objective: To investigate the role of central obesity on immunometabolic response in peripheral blood mononuclear cells (PBMCs) from normal weight and overweight/obese young men.

Methods: Eighteen individuals were classified as normal weight (NW; n = 9 - age: 25 ± 5 and BMI: 21.4 ± 1.

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The management of inflammatory bowel diseases has been widely investigated, especially ulcerative colitis. Thus, studies with the application of new probiotic products are needed in the prevention/treatment of these clinical conditions. The objective of this work was to evaluate the effects of probiotic orange juice containing Pediococcus acidilactici CE51 in a murine model of colitis.

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To investigate the impact of different exercise training schedules (following a fixed schedule or at random times of the day) on clock genes and myokine expression patterns in the skeletal muscle of tumor-bearing mice. Mice were divided into three groups: tumor (LLC), tumor + exercise training (LLC + T) always performed at the same time of the day (ZT2) and exercise training at random times of the day (ZTAlt). Mice were inoculated subcutaneously with Lewis lung carcinoma cells.

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Article Synopsis
  • The study aimed to assess the relationship between physical activity and immune/metabolic responses in young adults recovering from mild-to-moderate COVID-19 infection.
  • Researchers compared 20 post-COVID-19 patients with 20 healthy controls, evaluating factors like physical activity levels, body composition, and immune function.
  • Results showed lower physical activity levels and altered immune markers in post-COVID-19 patients, including decreased pulmonary function and changes in serum cytokines and lymphocyte activation compared to controls.
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  • - The study explores the long-term effects of COVID-19 on young adults, focusing on heart rate variability (HRV) as a way to assess the autonomic nervous system's (ANS) recovery after mild to moderate infection.
  • - Participants who had recovered from COVID-19 showed a decrease in sympathetic nervous system activity and an increase in parasympathetic nervous system activity during the follow-up assessment six weeks post-immunization, regardless of physical activity levels.
  • - Overall, the findings suggest that there is a recovery of ANS function in young adults after a COVID-19 infection, but this recovery is independent of changes in physical activity between the initial assessment and follow-up.
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Life expectancy has increased exponentially in the last century accompanied by disability, poor quality of life, and all-cause mortality in older age due to the high prevalence of obesity and physical inactivity in older people. Biologically, the aging process reduces the cell's metabolic and functional efficiency, and disrupts the cell's anabolic and catabolic homeostasis, predisposing older people to many dysfunctional conditions such as cardiovascular disease, neurodegenerative disorders, cancer, and diabetes. In the immune system, aging also alters cells' metabolic and functional efficiency, a process known as 'immunosenescence', where cells become more broadly inflammatory and their functionality is altered.

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The aim of this study was to investigate the metabolic and inflammatory fluctuations in two seasonal phases of badminton training, and the ability of youth badminton athletes to respond to an inflammatory challenge given by acute exercise on these markers. Thirteen youth badminton athletes who participated in national and international competitions were recruited. Metabolic and cytokine profile were measured at rest and in response to a maximal exercise intermittent test, in the pre- and final phases of a badminton annual season.

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Feeding pattern is related to health status or chronic diseases, and this depends on the individual's eating habits. Feeding organized with the right time to start and end during the day, promotes an internal biological rhythm, favoring molecular synchronization of the clock genes, which impose an effect on metabolism and immune cells, creating a physiological response related to a healthy profile. On the other hand, a feeding pattern disorganized, without the right time to start and end eating during the day, might lead to nonsynchronization of the clock genes, a disruption condition, which is related to chronic diseases, such as obesity and diabetes type 2.

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To evaluate the impact of exercise training plasma on prostate cancer cell viability and proliferation. PC3 prostate cancer cells were incubated with plasma obtained from young men with high and low physical fitness (PF) (high PF, = 5; low PF, = 5) and with the plasma collected from institutionalized older adults ( = 8) before and after multimodal exercise training. Cell viability and proliferation, mitochondria membrane polarization, reactive oxygen species (ROS) generation, and apoptosis were evaluated after the cell treatment with plasma.

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Background/objective: The quarantine caused by the COVID-19 pandemic increased sedentary behavior, psychological stress, and sleep disturbances in the population favoring the installation of alterations in the cardiovascular system. In this sense, physical exercise has widely been suggested as an efficient treatment to improve health. The current study determined the impact of short-term high-intensity circuit training (HICT) on resting heart rate variability (HRV) in adults.

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Since 2020, the world has been suffering from a pandemic that has affected thousands of people regardless of socio-economic conditions, forcing the population to adopt different strategies to prevent and control the advance of the disease, one of which is social distancing. Even though social distancing is a safe strategy to reduce the spread of COVID-19, it is also the cause of a rising sedentary behavior. This behavior develops an excess of fat tissue that leads to metabolic and inflammatory disruption related to chronic diseases and mental health disorders, such as anxiety, depression, and sleep issues.

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Background: The term immunometabolism describes cellular and molecular metabolic processes that control the immune system and the associated immune responses. Acute exercise and regular physical activity have a substantial influence on the metabolism and the immune system, so that both processes are closely associated and influence each other bidirectionally.

Scope Of Review: We limit the review here to focus on metabolic phenotypes and metabolic plasticity of T cells and macrophages to describe the complex role of acute exercise stress and regular physical activity on these cell types.

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Aim: This observational study aimed to examine cytokine responses to high-intensity intermittent exercise (HIIE) in the follicular and luteal phases of the menstrual cycle.

Methods: Fourteen healthy women (24 ± 2 years; body mass index [BMI]: 22.8 ± 1.

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To examine the effects of two high-intensity intermittent training (HIIT) programs of varying intensities (100% vs. 110% of maximal aerobic velocity [MAV]) on metabolic, hormonal and inflammatory markers in young men. Thirty-seven active male volunteers were randomly assigned into: HIIT experimental groups (100% MAV [EG, n = 9] and 110% MAV [EG, n = 9]) and a control groups (CG, n = 9 and CG, n = 9).

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Article Synopsis
  • COVID-19 can negatively affect the autonomic nervous system (ANS) and endothelial function, possibly causing lasting multiorgan issues even after recovery from the virus.
  • The study aimed to examine the ANS of young adults post-SARS-CoV-2 infection, focusing on how body mass index (BMI) and physical activity influence autonomic function in those both with and without the disease.
  • Findings showed that individuals recovering from COVID-19 displayed increased sympathetic nervous system activity and lower parasympathetic activity; overweight/obese and physically inactive participants experienced more pronounced disruptions in their ANS compared to their healthy counterparts.
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  • - The study analyzed the impact of adipose tissue hormones, body composition, and serum factors, particularly brain-derived neurotrophic factor (BDNF), on the clinical outcomes of 145 hospitalized COVID-19 patients.
  • - Findings revealed that while BDNF levels can predict the need for intensive care, especially in patients over 60, traditional adipose hormones like leptin and adiponectin proved less predictive of patient outcomes.
  • - The research suggests that the BDNF/adiponectin ratio may be a valuable marker for assessing the severity of COVID-19 in patients, highlighting the importance of considering age and sex differences in prognosis evaluations.
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Article Synopsis
  • This proposal addresses gaps in knowledge about COVID-19, focusing on immune, inflammatory, and metabolic markers while assessing the clinical and mental health of patients over time.
  • The study will involve a prospective observational cohort of adults with mild to moderate COVID-19 infection, measuring various health parameters at the start, six weeks post-vaccination, and at 12 months.
  • Participants will be categorized based on physical activity levels and body composition, and a sub-study will investigate the immune response using blood samples from both trained and sedentary individuals in relation to SARS-CoV-2.
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Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function.

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Due to hormonal fluctuation, the menstrual cycle impacts inflammatory response and lipid metabolism; moreover, the anti-atherogenic and anti-inflammatory effects of exercise in this cycle, mainly high-intensity intermittent exercise (HIIE), need to be examined. Therefore, the aim of the current study was to investigate the influence of menstrual cycle phases on adipokine and lipoprotein responses after acute HIIE sessions in healthy women. Fourteen women (age: 24 ± 2 years; BMI: 22.

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Background: Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men.

Methods: Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design.

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