Publications by authors named "Fabio Orlando"
Article Synopsis
- This study investigates the effects of low-intensity pulsed ultrasound (LIPUS) on Schwann cells (RSC96) and macrophages (THP-1) to understand its potential benefits for neuropathic inflammation.
- Researchers tested various ultrasound frequencies and intensities to identify settings that enhance cell metabolism and neurotrophic cytokine release in RSC96 cells, ultimately finding 5 MHz and 500 mW/cm² as optimal conditions.
- The study also reveals that these conditions reduce pro-inflammatory markers (like TNF-α and IL-8) in THP-1 cells while promoting anti-inflammatory responses, suggesting LIPUS could be a promising treatment for peripheral neuropathies.
It has been suggested that a primary tumor can "prepare" the draining of lymph nodes to "better accommodate" future metastatic cells, thus implying the presence of a premetastatic lymph node niche. However, this phenomenon remains unclear in gynecological cancers. The aim of this study was to evaluate lymph-node draining in gynecological cancers for premetastatic niche factors, such as myeloid-derived suppressor cells (MDSCs), immunosuppressive macrophages, cytotoxic T cells, immuno-modulatory molecules, and factors of the extracellular matrix.
View Article and Find Full Text PDFAims: To describe the incidence and impact of adverse clinical events (ACEs) during first 24 h of bedrest of patients after cardiac implantable electronic device (CIED) implantation.
Methods And Results: We conducted a prospective observational study of patients aged over 18 years undergoing elective placement of permanent bicameral pacemaker (PM), cardiac resynchronization therapy (CRT) PM, CRT defibrillator, or implantable cardioverter-defibrillator. Patients were maintained on bedrest post-operatively for 24 h and delirium, post-operative urinary retention, severe post-operative pain, pressure ulcer, and sleep disturbance were recorded using standardized assessments.
Objectives: To evaluate the effectiveness of needle-free connectors to maintain Central Venous Catheter-CVC patency.
Background: Loss of patency is a common complication associated with CVC. For patients, this can be stressful and painful, and can result in a delay in infusion therapy.