Publications by authors named "Fabio Noro"

Article Synopsis
  • - The study investigates the existence of the clinical-radiological paradox in multiple sclerosis (MS) patients by analyzing the relationship between lesion load and clinical disability.
  • - Using MRI data from 95 patients, researchers found a positive correlation between higher lesion loads and increased disability, particularly in specific brain regions such as the posterior fossa and spinal cord.
  • - The findings suggest that the clinical-radiological paradox may not exist, supporting the idea that lesion locations in MS are logically associated with neurological impairment.
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Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01.

Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS.

Methods: We retrospectively studied data from 95 consecutive patients with MS.

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Objective: Multiple cerebral cavernous malformation (CCM) is the hallmark of familial presentation of cavernous malformation in the brain. We describe an ongoing Familial Cerebral Cavernous Malformation Project in the Rio de Janeiro state showing genetic profile and the pattern of emergent neuroimaging findings of this particular population besides a review of the updated recommendations for management of familial CCM versus patients harboring sporadic lesions.

Method: Four families of our cohort of 9 families were genetically mapped showing mutational profile linked to CCM1.

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