Glycerol derived from biodiesel can replace maize in diets for juvenile silver catfish (Rhamdia quelen).

The aim of the present study was to evaluate the effect of maize replacement by crude biodiesel-derived glycerol on the zootechnical performance, chemical carcass composition and blood parameters of silver catfish (Rhamdia quelen) juveniles. A total of 600 silver catfish juveniles were distributed in a completely randomized design with six treatments comprised of isoproteic and isoenergetic pelleted diets with six levels of glycerol replacing maize, and five replicates. The glycerol maize substitution significantly influenced (p < 0.

Ivy Leaf Dry Extract EA 575 Has an Inhibitory Effect on the Signalling Cascade of Adenosine Receptor A.

Ivy leaf dry extract EA 575 is used to improve complaints of chronic inflammatory bronchial diseases and acute inflammation of the respiratory tract accompanied by coughing. Its mechanism of action has so far been explained by influencing β-adrenergic signal transduction. In the present study, we investigated a possible influence on adenosine receptor A (AAR) signalling, as it has been described to play a significant and detrimental role in chronic inflammatory airway diseases.

Ivy leaves dry extract EA 575® mediates biased β-adrenergic receptor signaling.

Background: β-adrenergic receptor (β-AR) stimulation activates the G protein/cAMP pathway, which is opposed by the GRK2/β-arrestin 2 pathway. The latter is undesirable in the treatment of respiratory diseases.

Hypothesis/purpose: EA 575® is capable of mediating a biased β-adrenergic signaling pathway.

Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose.

Melatonin is a hormone related to circadian rhythms and has potential clinical applications. Our objectives were to verify the effect of melatonin on the liver of zebrafish exposed to fructose and evaluate the expression of appetite-related genes (leptin, ghrelin, and melanocortin receptor 4 [MC4R]). Animals were divided into three groups: control (CG,  = 25), fructose (FG,  = 25), and fructose+melatonin (FMG,  = 25).

Effect of dietary crude glycerin on the productive performance of Nile tilapia fingerlings.

The aim of this study was to evaluate the effect of different crude glycerin levels in the diet of Nile tilapia fingerlings (mean initial weight 0.32 ± 0.06 g, n = 450) on growth performance parameters, whole-body composition, blood glucose and liver morphology.

A comparative study on the influence of an ivy preparation and an ivy/thyme combination on the β-adrenergic signal transduction.

The β-adrenergic receptor (βAR) is relevant for surfactant formation in alveolar type 2 cells and reduction of intracellular calcium concentration in bronchial muscle cells and thus for secretolytic and bronchospasmolytic effects. Herbal medicinal products that affect the βAR system are used to treat common cold and bronchitis accompanied with mucus covered and narrowed airways. The present work compares the influence of an ivy preparation and an ivy/thyme combination on the β-adrenergic signal transduction.

Hepatoprotective Effect of Probiotic GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish.

Alcoholic liver disease (ALD) is among the leading causes of death from liver disease. Among the factors involved in its pathogenesis are inflammation and increased intestinal permeability. The aim of this study was to assess the effect of GG (LGG) on hepatic lipid accumulation, activation of inflammasomes, and gut permeability markers in experimental model of ALD with zebrafish.

Alcoholic extract of propolis in Nile tilapia post-larvae and fingerlings' diets: effects on production performance, body composition and intestinal histology.

The aim of this study was to evaluate the production performance of Nile tilapia post-larvae and fingerlings fed with increasing levels of alcoholic extract of propolis into diets. In Experiment 1, 1800 post-larvae were distributed in 30 tanks, in a completely randomized design with five treatments composed by the inclusion of 0, 1, 2, 3 and 4 g of dry propolis/kg of feed, and six replicates. In experiment 2, 1600 fingerlings were distributed in the same system and designed as experiment 1.

Effects of Lactobacillus rhamnosus GG on hepatic and serum lipid profiles in zebrafish exposed to ethanol.

Zebrafish is a powerful tool in pharmacological research and useful to identify new therapies. Probiotics can offer therapeutic options in alcoholic liver disease. This study was done in two independent experiments: first, we confirmed the intestinal colonization of probiotic Lactobacillus rhamnosus GG (LGG) after ethanol exposure.