The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I-Associated Peptides.

Tumor antigens can emerge through multiple mechanisms, including translation of noncoding genomic regions. This noncanonical category of tumor antigens has recently gained attention; however, our understanding of how they recur within and between cancer types is still in its infancy. Therefore, we developed a proteogenomic pipeline based on deep learning de novo mass spectrometry (MS) to enable the discovery of noncanonical MHC class I-associated peptides (ncMAP) from noncoding regions.

Syntax and prejudice: ethically-charged biases of a syntax-based hate speech recognizer unveiled.

Hate speech recognizers (HSRs) can be the panacea for containing hate in social media or can result in the biggest form of prejudice-based censorship hindering people to express their true selves. In this paper, we hypothesized how massive use of syntax can reduce the prejudice effect in HSRs. To explore this hypothesis, we propose Unintended-bias Visualizer based on Kermit modeling (): a syntax-based HSR, which is endowed with syntax heat parse trees used as a post-hoc explanation of classifications.

Data Augmentation Using Background Replacement for Automated Sorting of Littered Waste.

The introduction of sophisticated waste treatment plants is making the process of trash sorting and recycling more and more effective and eco-friendly. Studies on Automated Waste Sorting (AWS) are greatly contributing to making the whole recycling process more efficient. However, a relevant issue, which remains unsolved, is how to deal with the large amount of waste that is littered in the environment instead of being collected properly.

Evaluating diagnostic content of AI-generated radiology reports of chest X-rays.

Radiology reports are of core importance for the communication between the radiologist and clinician. A computer-aided radiology report system can assist radiologists in this task and reduce variation between reports thus facilitating communication with the medical doctor or clinician. Producing a well structured, clear, and clinically well-focused radiology report is essential for high-quality patient diagnosis and care.

Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey.

Artificial Intelligence is providing astonishing results, with medicine being one of its favourite playgrounds. Machine Learning and, in particular, Deep Neural Networks are behind this revolution. Among the most challenging targets of interest in medicine are cancer diagnosis and therapies but, to start this revolution, software tools need to be adapted to cover the new requirements.

Symbolic, Distributed, and Distributional Representations for Natural Language Processing in the Era of Deep Learning: A Survey.

Natural language is inherently a discrete symbolic representation of human knowledge. Recent advances in machine learning (ML) and in natural language processing (NLP) seem to contradict the above intuition: discrete symbols are fading away, erased by vectors or tensors called and . However, there is a strict link between distributed/distributional representations and discrete symbols, being the first an approximation of the second.

Machine learning approach to predict medication overuse in migraine patients.

Machine learning (ML) is largely used to develop automatic predictors in migraine classification but automatic predictors for medication overuse (MO) in migraine are still in their infancy. Thus, to understand the benefits of ML in MO prediction, we explored an automated predictor to estimate MO risk in migraine. To achieve this objective, a study was designed to analyze the performance of a customized ML-based decision support system that combines support vector machines and Random Optimization (RO-MO).

Breast Cancer Prognosis Using a Machine Learning Approach.

Machine learning (ML) has been recently introduced to develop prognostic classification models that can be used to predict outcomes in individual cancer patients. Here, we report the significance of an ML-based decision support system (DSS), combined with random optimization (RO), to extract prognostic information from routinely collected demographic, clinical and biochemical data of breast cancer (BC) patients. A DSS model was developed in a training set ( = 318), whose performance analysis in the testing set ( = 136) resulted in a C-index for progression-free survival of 0.

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models.

Risk prediction of chemotherapy-associated venous thromboembolism (VTE) is a compelling challenge in contemporary oncology, as VTE may result in treatment delays, impaired quality of life, and increased mortality. Current guidelines do not recommend thromboprophylaxis for primary prevention, but assessment of the patient's individual risk of VTE prior to chemotherapy is generally advocated. In recent years, efforts have been devoted to building accurate predictive tools for VTE risk assessment in cancer patients.

Validation of a Machine Learning Approach for Venous Thromboembolism Risk Prediction in Oncology.

Using kernel machine learning (ML) and random optimization (RO) techniques, we recently developed a set of venous thromboembolism (VTE) risk predictors, which could be useful to devise a web interface for VTE risk stratification in chemotherapy-treated cancer patients. This study was designed to validate a model incorporating the two best predictors and to compare their combined performance with that of the currently recommended Khorana score (KS). Age, sex, tumor site/stage, hematological attributes, blood lipids, glycemic indexes, liver and kidney function, BMI, performance status, and supportive and anticancer drugs of 608 cancer outpatients were all entered in the model, with numerical attributes analyzed as continuous values.

Risk Assessment for Venous Thromboembolism in Chemotherapy-Treated Ambulatory Cancer Patients.

Objective: To design a precision medicine approach aimed at exploiting significant patterns in data, in order to produce venous thromboembolism (VTE) risk predictors for cancer outpatients that might be of advantage over the currently recommended model (Khorana score).

Design: Multiple kernel learning (MKL) based on support vector machines and random optimization (RO) models were used to produce VTE risk predictors (referred to as machine learning [ML]-RO) yielding the best classification performance over a training (3-fold cross-validation) and testing set.

Results: Attributes of the patient data set ( n = 1179) were clustered into 9 groups according to clinical significance.