Molecular cloning and structural modelling of gamma-phospholipase A inhibitors from Bothrops atrox and Micrurus lemniscatus snakes.

Phospholipases A inhibitors (PLIs) produced by venomous and non-venomous snakes play essential role in this resistance. These endogenous inhibitors may be classified by their fold in PLIα, PLIβ and PLIγ. Phospholipases A (PLAs) develop myonecrosis in snake envenomation, a consequence that is not efficiently neutralized by antivenom treatment.