Publications by authors named "Fabio Levi"

We provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cuba, and Mexico), focusing on prostate cancer. We extracted mortality data for all cancers combined and the most common sites from the WHO and population data since 1970 from the United Nations. Estimates for 2025 were computed applying a linear regression to the most recent segment identified through Poisson join-point regression.

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Introduction: The relations between coffee and tea consumption and head and neck cancer (HNC) incidence are unclear. With increasing global HNC burden, this study aims to examine the association between coffee, tea, and HNC.

Methods: A pooled analysis of 9548 HNC cases and 15,783 controls from 14 individual-level case-control studies was conducted from the International Head and Neck Cancer Epidemiology consortium.

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Article Synopsis
  • The American Cancer Society suggests that doctors should talk to women about endometrial cancer risks when they reach menopause, but more younger women under 50 are being diagnosed.
  • A study looked at nearly 14,000 women with endometrial cancer and found that factors like body weight and diabetes increase the risk for both younger and older women.
  • Educating women about these risk factors could help reduce the number of cases, as many endometrial cancer cases in both age groups are linked to these factors.
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Introduction: We estimated cancer mortality figures in five major Asian countries and Australia for 2024, focusing on stomach cancer, a leading cause of cancer-related deaths in Eastern Asia.

Methods: We computed country- and sex-specific annual age-standardized rates (ASRs) for total cancers and the 10 most common cancer sites, using WHO and the United Nations Population Division databases from 1970 to 2021 or the latest available year. We predicted figures for 2024 and estimated the number of avoided cancer deaths in 1994-2024.

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Background: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for endometrial cancer. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of endometrial cancer remains unclear.

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Mortality from cutaneous malignant melanoma (CMM) increased in the past, but trends have been favorable in more recent years in many high-income countries. However, incidence has been increasing in several countries. We provided an up-to-date overview of mortality trends from CMM.

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Evidence on the relationship between legume consumption and risk of specific cancer sites is inconclusive. We used data from a series of case-controls studies, conducted in Italy and in the Swiss Canton of Vaud between 1991 and 2009 to quantify the association between legume consumption and several cancer sites including oral cavity, esophagus, larynx, stomach, colorectum, breast, endometrium, ovary, prostate and kidney. Multiple logistic regression models controlled for sex, age, education, smoking, alcohol, body mass index, physical activity, comorbidities, and consumption of fruit, vegetables, processed meat and total calorie intake were used to estimate the odds ratios (OR) for different cancer sites and their corresponding 95% confidence intervals(CI).

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Objective: Anal cancer is a rare disease, affecting more frequently women than men, mainly related to human papillomavirus infection (HPV). Rising incidence and mortality have been reported over the past four decades in different countries.

Methods: To provide an up-to-date overview of recent trends in mortality from anal cancer, we analysed death certification data provided by the WHO in selected countries worldwide over the period from 1994 to 2020.

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Background: Esophageal cancer (EC) is a malignancy with a poor prognosis. We provided a global overview of EC mortality, analyzing figures over the last three decades and estimating mortality rates for the year 2025. We also reported incidence trends and the distribution of squamous cell carcinoma (SCC) and adenocarcinoma (AC) in selected countries.

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Objective: We estimated cancer mortality statistics for the current year in seven major Latin American countries.

Methods: We retrieved official death certification data and population figures from the WHO and the United Nations databases for the 1970-2020 calendar period. We considered mortality from all neoplasms combined and for 10 major cancer sites.

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  • Researchers created endometrial cancer risk prediction models using data from postmenopausal White women in 19 studies to improve interventions and screenings for this rising cancer risk.
  • The models demonstrated modest predictive ability, with area under the curve values (ranging from 0.64 to 0.69), and the addition of genetic factors slightly improved predictions in some cohorts.
  • The epidemiologic-based model effectively identified high-risk women but showed variations in performance across different cohorts, indicating a need for refinement and adaptation for diverse populations.
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Objective: The epidemiological evidence on soft-tissue sarcoma (STS) mortality is inconsistent in geographic and time coverage. This study provides mortality trends for STSs in selected countries worldwide over the last 2 decades, together with predicted figures for 2025.

Methods: We extracted official numbers of certified deaths coded as C47 (i.

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Background: Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating concentrations of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects.

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  • A study in Italy and Switzerland analyzed data from over 6,400 participants, including women with breast cancer (BC) and healthy controls, to investigate how multiple health conditions influence BC risk.
  • Different patterns of comorbidities were identified, revealing that 'metabolic disorders' and 'breast diseases' were linked to higher BC risk, while certain surgical histories seemed to provide a protective effect.
  • The findings emphasize the importance of understanding these comorbidity patterns, as they can aid in improving patient care and management strategies in healthcare settings.
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  • A study aimed to analyze and update COPD mortality data globally using WHO statistics from up to 2019, focusing on variations across different countries.
  • Overall, COPD mortality rates decreased among men in Europe and the U.S. but increased among women during 2005-2017, highlighting a concerning trend.
  • The findings suggest that changing smoking habits, along with factors like air pollution and occupational risks, significantly influence these mortality trends, especially in countries with lower socio-economic development.
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Objective: We aimed at predicting cancer mortality rates for the current year for the Russian Federation, Ukraine, Israel, Hong Kong SAR, Japan, Korea, and Australia, with a focus on colorectal cancer.

Methods: We retrieved official death certification and population data from the WHO and the United Nations Population Division databases. We analyzed mortality for all cancers combined and for 10 major cancer sites from 1970 to 2019, or the latest available year.

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  • The study analyzed data from the INHANCE consortium to compare the effects of cigarette smoking and alcohol consumption on head and neck cancer risk in less developed and more developed countries.
  • It found that the risk profiles associated with smoking and alcohol use vary between these country types, with specific cancers showing different patterns of risk.
  • The research highlights how factors like industrialization and economic development influence the relationship between lifestyle habits (smoking and drinking) and head and neck cancer incidence.
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Background: Ovarian cysts represent a common condition among women. Epidemiologic studies are inconsistent in determining if women with cysts are more likely to develop endometrial cancer (EC) regardless of overweight/obesity. We investigated the combined role of cysts and body mass index (BMI) on EC risk.

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Objective: To identify body mass index (BMI) trajectories in adult life and to examine their association with endometrial cancer (EC) risk, also exploring whether relations differ by hormonal replacement therapy use.

Design: Pooled analysis of two case-control studies.

Setting: Italy and Switzerland.

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We estimated cancer mortality statistics for the current year in seven major Latin American countries, with a focus on colorectal cancer. We retrieved official death certification data and population figures from the World Health Organization and the Pan American Health Organization databases. We analysed mortality from all neoplasms combined and for selected cancer sites.

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  • Childhood cancer mortality has seen significant declines in high-income regions like North America and Australasia, with rates dropping 2-3% annually, while Latin American countries show limited progress.
  • Data analysis from 1990 to 2017 highlights better outcomes for leukemia, but Central Nervous System (CNS) tumors show less favorable trends, especially in Latin America.
  • The study emphasizes the need for improved cancer care in lower-income nations to bridge the mortality gap and enhance outcomes for all children diagnosed with cancer.
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  • Recent analysis of male breast cancer mortality trends globally reveals significant variations, with Central-Eastern Europe and Russia experiencing the highest death rates in 2015-2017.
  • Data from 2000-2017 shows a decrease in age-adjusted death rates in North-Western Europe, Russia, and the USA, while Latin America saw a slight increase.
  • Improvements in cancer management are attributed to the overall decrease in mortality rates; however, delayed diagnosis and poor access to healthcare contribute to higher mortality rates in certain regions.*
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Objectives: Predicted cancer mortality figures are useful for public health planning. We predicted cancer mortality rates in Israel, Hong Kong, Japan, the Philippines, Korea, Australia, Russia and Ukraine for the year 2020 using the most recent available data. We focused on breast cancer.

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Background: The considerable differences in food consumption across countries pose major challenges to the research on diet and cancer, due to the difficulty to generalise and reproduce the dietary patterns identified in a specific population.

Methods: We analysed data from a multicentric case-control study on oesophageal squamous cell carcinoma (ESCC) carried out between 1992 and 2009 in three Italian areas and in the Canton of Vaud, Switzerland, which included 505 cases and 1259 hospital controls. Dietary patterns were derived applying LCA on 24 food groups, controlling for country membership, and non-alcoholic energy intake.

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