Publications by authors named "Fabio Levantesi"

Article Synopsis
  • Type-2 diabetes often coexists with cirrhosis, negatively impacting complications and mortality rates among patients.
  • A study analyzing data from the ANSWER trial focused on 85 patients receiving long-term human albumin (HA) in addition to standard treatment, revealing improved survival rates (86% vs. 57%) and fewer complications.
  • The HA group experienced fewer instances of complications like infections and renal issues, although overall hospital admissions were similar between groups, with shorter hospital stays for those receiving HA.
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Article Synopsis
  • This study examined the effects of long-term albumin treatment on hyponatremic patients with ascites from the ANSWER trial.
  • Results showed that albumin treatment significantly improved the normalization of low sodium levels compared to standard care.
  • Additionally, patients receiving albumin had a lower incidence of moderate hyponatremia over 18 months, suggesting it is a more effective management option for these patients.
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Background & Aims: The ANSWER study reported that long-term albumin administration in patients with cirrhosis and uncomplicated ascites improves survival. During treatment, serum albumin increased within a month and remained stable thereafter. In this post hoc analysis, we aimed to determine whether on-treatment serum albumin levels could guide therapy.

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Background: Chronic hepatitis B virus (HBV) infection remains a primary cause of morbidity and mortality worldwide.

Aim: The study is aimed at updating the clinical and epidemiological profile of chronic HBV infection in Italy.

Methods: A cross-sectional multicenter prospective study enrolled consecutive HBsAg positive patients seen in 73 Italian centers in the period 2012-2015.

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Background: Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue.

Methods: We did an investigator-initiated multicentre randomised, parallel, open-label, pragmatic trial in 33 academic and non-academic Italian hospitals.

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Treatment options for chronic hepatitis B (CHB) are pegylated interferon (Peg-IFN) in minimal-mild liver fibrosis and nucleot(s)ide analogues (NUC) in more advanced disease. Since little is known about their use in daily clinical practice, we conducted a multicentre prospective study to investigate treatment regimens applied to naïve CHB patients in real life. HBV-RER is an observational multicentre Italian network that collect clinic and virologic data of patients with CHB.

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