Publications by authors named "Fabio H da Silva"
This study focused on investigating the water quality in the Pirajibú River, a relevant water body that flows through the industrial zone of Sorocaba (São Paulo/Brazil). Due to the limitations of assessing water quality based solely on standard physicochemical tests, an ecotoxicological approach was used to assess biomarker changes in the liver of bullfrog tadpoles (Aquarana catesbeiana). The animals were divided into groups and exposed to water samples collected upstream and downstream of the industrial zone.
View Article and Find Full Text PDFAims: To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity.
Methods: C57BL/6 male mice were fed with standard chow or high-fat diet for 12 weeks. Lean and obese mice were treated orally with mirabegron (10 mg/kg/day) from the last 2 weeks of diet.
Article Synopsis
- Urological issues linked to sickle cell disease (SCD) include problems like frequent urination, bedwetting, and urinary infections, but the exact causes for these symptoms are not well understood.
- This study aimed to assess urinary function in a mouse model of SCD, particularly focusing on how their bladders and urinary systems perform.
- Findings revealed that SCD mice showed significantly reduced urine output and bladder contraction capabilities, alongside structural abnormalities in their bladders, indicating dysfunction in the urinary system related to SCD.
The nitric oxide-cGMP signaling pathway modulates the ejaculatory functions. The nitric oxide (NO)-independent soluble guanylate cyclase haem-dependent stimulator BAY 41-2272 potently relaxes different types of smooth muscles. However, no study investigated its effects in vas deferens smooth muscle.
View Article and Find Full Text PDFObjective: • To investigate the potential beneficial effects of 4-week oral treatment with 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1Hpyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine (BAY 41-2272), a nitric oxide (NO)-independent soluble guanylate cyclase activator, on impaired rat corpus cavernosum relaxations in NO-deficient rats.
Material And Methods: • Male Wistar rats were divided into four groups: Control, N (G)-nitro-L- arginine methyl ester (L-NAME; 20 mg/rat/day), BAY 41-2272 (20 mg/kg/day) and L-NAME + BAY 41-2272. • Rats were treated with L-NAME concomitantly with BAY 41-2272 for 4 weeks.
Objective: • Obesity induced by high-fat diet (HFD) is one of the most important risk factor for the development of erectile dysfunction (ED) in man. This study aimed to characterize the ED resulting from obesity associated with HFD in mice.
Materials And Methods: • C57BL/6 mice fed for 10 weeks with either HFD to induce obesity or a standard-chow diet (SD) were used.