Publications by authors named "Fabio Guglietta"

We develop a numerical method for simulating the dynamics of a droplet immersed in a generic time-dependent velocity gradient field. This approach is grounded on the hybrid coupling between the lattice Boltzmann (LB) method, employed for the flow simulation, and the immersed boundary (IB) method, utilized to couple the droplet with the surrounding fluid. We show how to enrich the numerical scheme with a mesh regularization technique, allowing droplets to sustain large deformations.

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The tumbling to tank-treading (TB-TT) transition for red blood cells (RBCs) has been widely investigated, with a main focus on the effects of the viscosity ratio [Formula: see text] (i.e., the ratio between the viscosities of the fluids inside and outside the membrane) and the shear rate [Formula: see text] applied to the RBC.

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We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between the loading (L) dynamics, following the imposition of the mechanical load on the RBC at rest, and the relaxation (R) dynamics, allowing the RBC to relax to its original shape after the sudden arrest of the mechanical load. Such a comparison is carried out by analyzing the characteristic times of the two corresponding dynamics, i.

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Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red blood cells (RBCs) at the mesoscale. In many practical instances, biomedical devices work on time-scales comparable to the intrinsic relaxation time of RBCs: thus, a systematic understanding of the time-dependent response of erythrocyte membranes is crucial for the effective design of such devices. So far, this information has been deduced from experimental data, which do not necessarily adapt to the broad variety of fluid dynamic conditions that can be encountered in practice.

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