Publications by authors named "Fabio D'Amici"
Asn25 Deamidation as an Allosteric Tool to Increase IFNβ-1a Biological Activity.
J Interferon Cytokine Res
June 2022
Interferon beta (IFNβ) is a well-known cytokine, belonging to the type I family, that exerts antiviral, immunomodulatory, and antiproliferative activity. It has been reported that the artificially deamidated form of recombinant IFNβ-1a at Asn25 position shows an increased biological activity. As a deepening of the previous study, the molecular mechanism underlying this biological effect was investigated in this work by combining experimental and computational techniques.
View Article and Find Full Text PDFHuman type I interferons are a family of pleiotropic cytokines with antiviral, anti-proliferative and immunomodulatory activities. They signal through the same cell surface receptors IFNAR1 and IFNAR2 yet evoking markedly different physiological effects. One differentiating factor of interferon-beta (IFN-β) from other type I interferons is the presence of theAsn-Gly-Arg (NGR) sequence motif, which, upon deamidation, converts to Asp-Gly-Arg (DGR) and iso-Asp-Gly-Arg (iso-DGR) motifs.
View Article and Find Full Text PDFArticle Synopsis
- Biosimilars are biological products that mimic existing approved products, requiring extensive analysis to demonstrate similarity in structure and function.
- A comparative study was conducted between the proposed biosimilar adalimumab MSB11022 and its reference product, Humira®, using advanced methods to analyze their physicochemical and functional properties across multiple batches.
- Results showed high similarity between MSB11022 and Humira®, with comparable purity and efficacy in functional tests, suggesting that MSB11022 may be as safe and effective as Humira®.