Publications by authors named "Fabio Bonorino"
Article Synopsis
- Marfan syndrome (MFS) causes problems with blood vessels, specifically aortic aneurysms, due to improper proteins and signaling in the body.
- Scientists studied a protein called NOX4 that is linked to these aneurysms to understand how it affects their growth and structure in mice with MFS.
- They found that NOX4 helps damage the blood vessels in MFS, and blocking it can make the vessels stronger and healthier.
Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-threatening aortic aneurysm, which initiates at the aortic root and can progress into the ascending portion. However, analysis of ascending aorta reactivity in animal models of MFS has remained elusive. Epidemiologic evidence suggests that although MFS is equally prevalent in men and women, men are at a higher risk of aortic complications than non-pregnant women.
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- Marfan syndrome causes serious cardiovascular issues, including aortic root dilation and heart problems, but there is limited evidence on the effects of exercise in these patients.
- A study using a transgenic mouse model showed that moderate dynamic exercise for five months reduced aortic root dilation rates and helped regress cardiac hypertrophy in mice with Marfan syndrome compared to those that were sedentary.
- Overall, the findings suggest that moderate exercise may have a protective effect on the cardiovascular symptoms associated with Marfan syndrome, challenging the previous recommendations against dynamic sports for these patients.