Computational insights into CRISP3 downregulation in cervical cancer and its cervical lineages pattern.

Background: Cysteine-rich secretory protein 3 (CRISP3) emerges as a potential biomarker in the study of many cancers, including cervical cancer (CC). This study aimed to analyze the expression pattern of CRISP3 in CC patients and CC cell lineages, following treatment with the epigenetic drugs: trichostatin A (TSA) and 5-aza-2'-deoxycytidine (5-aza).

Methods: The differentially expressed genes identified in GSE63514 were used to construct a protein-protein interaction network.