Publications by authors named "Fabienne Maibach"
Article Synopsis
- The study aimed to explore changes in iron deposition in the pulvinar of epilepsy patients using a specific MRI technique called susceptibility weighted imaging (SWI) and a biomarker known as the "hypointense pulvinar sign."
- Researchers analyzed radiological reports from 2014 to 2022, focusing on epilepsy patients and found that the hypointense pulvinar sign was correct in 44% of cases, with right hemispheric lesions showing higher accuracy compared to left.
- The study concluded that the hypointense pulvinar sign is a reliable and straightforward biomarker for detecting iron deposition in epilepsy, suggesting its potential use in precision medicine approaches.
Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB) antibodies, have demonstrated the capacity of the immune system to fight cancer in a number of malignancies such as melanoma and lung cancer. The numbers, localization and phenotypes of tumor-infiltrating lymphocytes (TIL) are not only predictive of response to immunotherapy but also key modulators of disease progression. In this review, we focus on TIL profiling in cutaneous melanoma using histopathological approaches and highlight the observed prognostic value of the primary TIL subsets.
View Article and Find Full Text PDFMyeloid cells orchestrate the antitumor immune response and influence the efficacy of immune checkpoint blockade (ICB) therapies. We and others have previously shown that IL-32 mediates DC differentiation and macrophage activation. Here, we demonstrate that IL-32 expression in human melanoma positively correlates with overall survival, response to ICB, and an immune-inflamed tumor microenvironment (TME) enriched in mature DC, M1 macrophages, and CD8+ T cells.
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