Publications by authors named "Fabienne Fobe"
Article Synopsis
- The study investigated how variations in the CYP2D6 gene affect the body’s response to tramadol and its active form, O-dT, in European adult patients after surgery.
- Researchers classified participants' CYP2D6 metabolizer types (EM, IM, PM, UM) and measured the O-dT/T ratio in their plasma to see if it could effectively indicate their CYP2D6 phenotype.
- Results showed that while the O-dT/T ratio was lower in poor metabolizers (PM) compared to non-PM, there was significant overlap between groups, indicating that tramadol is not a reliable drug for accurately determining CYP2D6 phenotypes.
Background: The aim of this study was to investigate whether the implementation of enhanced recovery after surgery (ERAS) guidelines according to Thorell and co. in our tertiary referral bariatric center might improve post-operative outcomes.
Methods: ERAS program was introduced in our center since January 1, 2017.