Radiographic evaluation of a bone substitute material in alveolar ridge preservation for maxillary removable immediate dentures: A randomized controlled trial.

Statement Of Problem: Maxillary bone resorption after multiple extractions can jeopardize the success of an immediate denture, but whether bone volume preservation techniques are effective is unclear.

Purpose: The purpose of this randomized controlled trial was to evaluate the efficacy of socket grafting with a xenogenic bone substitute in participants receiving maxillary immediate removable complete dentures in terms of bone volume preservation (height and width of the bone ridge).

Material And Methods: The study was a single-blinded, randomized controlled clinical trial with 2 balanced parallel arms.

European survey on criteria of aesthetics for periodontal evaluation: The ESCAPE study.

Objective: The ESCAPE multicentre survey was designed to (a) compare the agreement of three relevant aesthetic scoring systems among different centres, and (b) evaluate the reproducibility of each question of the questionnaires.

Materials And Methods: EFP centres (n = 14) were involved in an e-survey. Forty-two participants (28 teachers, 14 postgraduate students) were asked to score the one-year aesthetic outcomes of photographs using the Before-After Scoring System (BASS), the Pink Esthetic Score (PES) and the Root coverage Esthetic Score (RES).

Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients.

Background: Identification of predictive markers of response to treatment is a major objective in breast cancer. A major problem in clinical sampling is the variability of RNA templates, requiring accurate management of tumour material and subsequent analyses for future translation in clinical practice. Our aim was to establish the feasibility and reliability of high throughput RNA analysis in a prospective trial.

Power estimation of tests in log-linear non-uniform association models for ordinal agreement.

Background: Log-linear association models have been extensively used to investigate the pattern of agreement between ordinal ratings. In 2007, log-linear non-uniform association models were introduced to estimate, from a cross-classification of two independent raters using an ordinal scale, varying degrees of distinguishability between distant and adjacent categories of the scale.

Methods: In this paper, a simple method based on simulations was proposed to estimate the power of non-uniform association models to detect heterogeneities across distinguishabilities between adjacent categories of an ordinal scale, illustrating some possible scale defects.

High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients.

A high percentage of uveal melanoma patients develop metastatic tumors predominantly in the liver. We studied the molecular profiles derived from gene expression microarrays and comparative genomic hybridization microarrays, to identify genes associated with metastasis in this aggressive cancer. We compared 28 uveal melanomas from patients who developed liver metastases within three years of enucleation with 35 tumors from patients without metastases or who developed metastases more than 3 years after enucleation.

Relationship between sponsorship and failure rate of dental implants: a systematic approach.

Background: The number of dental implant treatments increases annually. Dental implants are manufactured by competing companies. Systematic reviews and meta-analysis have shown a clear association between pharmaceutical industry funding of clinical trials and pro-industry results.

Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.

Regulatory T (Treg) cells limit the onset of effective antitumor immunity, through yet-ill-defined mechanisms. We showed the rejection of established ovalbumin (OVA)-expressing MCA101 tumors required both the adoptive transfer of OVA-specific CD8(+) T cell receptor transgenic T cells (OTI) and the neutralization of Foxp3(+) T cells. In tumor-draining lymph nodes, Foxp3(+) T cell neutralization induced a marked arrest in the migration of OTI T cells, increased numbers of dendritic cells (DCs), and enhanced OTI T cell priming.

A comparison of methods of aesthetic assessment in root coverage procedures.

Aim: To evaluate the reliability of professional qualitative scoring methods used in evaluating aesthetic results after root coverage therapy and to evaluate the relationship between subjective and objective measurements.

Material And Methods: A review panel of seven professional and non-professional, trained and untrained observers used photographic records to assess the overall cosmetic results of 162 root coverage surgical procedures in 133 patients (mean follow-up 17.51+/-17.

Quality assessment of ordinal scale reproducibility: log-linear models provided useful information on scale structure.

Objective: In health research, ordinal scales are extensively used. Reproducibility of ratings using these scales is important to assess their quality. This study aimed to compare two methods analyzing reproducibility: weighted Kappa statistic and log-linear models.

Log-linear non-uniform association models for agreement between two ratings on an ordinal scale.

In agreement studies, when objects are rated independently by two raters (or twice by the same rater), an association between their ratings on two categories arises, reflecting the distinguishability of these two categories for these raters. When ratings are performed on an ordinal scale, this association between ratings on two categories increases when the distance between these categories increases on the ordinal scale. Goodman's log-linear models derived for the analysis of agreement between two raters on an ordinal scale assume that distinguishabilities between adjacent categories are either constant, or a priori fixed.