Publications by authors named "Fabien Robin"
Background & Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Liver transplantation (LT) is a curative treatment option. We investigated survival outcomes based on recipient-donor sex constellation (RDSC) following LT.
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- When liver transplants are done at night, doctors wanted to see if it causes more problems afterwards.
- They looked at 790 patients who had liver transplants from 2012 to 2018.
- The study found that transplants done late at night had more serious complications and needed more blood transfusions compared to those done during the day.
Background: The impact of cirrhosis on the postoperative outcomes of distal pancreatectomy is yet to be reported. We aimed to evaluate the outcomes of distal pancreatectomy in patients with cirrhosis.
Methods: We conducted a retrospective, multicentric study patients with cirrhosis who underwent planned distal pancreatectomy between 2008 and 2020 in French high volume centers.
Article Synopsis
- Minimally invasive surgery (MIS) for left pancreatic resections has been increasingly utilized, but its advantages over traditional open surgery for distal pancreatectomy in treating pancreatic neuroendocrine tumors are still debated.
- A retrospective study involving 274 patients across 21 French centers analyzed short and long-term outcomes of MIS versus open surgery, focusing on factors like tumor size and patient characteristics.
- Results showed that MIS reduced major complications and delayed gastric emptying while maintaining comparable survival rates, suggesting it is a safe option for patients with resectable left pancreatic neuroendocrine tumors.
Article Synopsis
- Uterine innervation is crucial to female reproductive health and has significant implications for conditions like endometriosis; recent histological advances have revealed its complex structure and role in these disorders.
- This review summarizes current research on uterine innervation, focusing on its effects on endometriosis and associated pain, using a systematic approach to analyze relevant studies.
- The review identified 45 studies that highlighted a trend towards increased nerve fiber density in ectopic endometrial tissue, suggesting a link between this heightened innervation and the chronic pain seen in endometriosis patients.
Article Synopsis
- Pelvic gynecological surgeries often lead to complications due to damage to the autonomic nervous system, and recognizing the deep uterine vein (DUV) can help prevent this.
- A systematic literature review and anatomical studies were conducted to better understand the DUV's structure and role in surgical settings, utilizing cadaver dissections and advanced imaging techniques.
- The research confirmed the DUV's importance in dividing uterine regions and assisting surgeons in navigating the subperitoneal anatomy to reduce the risk of nerve and ureter injuries during procedures.
Objective: The aim of this study was to evaluate the efficacy of yttrium-90 transarterial radioembolization (TARE) to convert to resection initially unresectable, single, large (≥5 cm) hepatocellular carcinoma (HCC).
Background: TARE can downsize cholangiocarcinoma to resection but its role in HCC resectability remains debatable.
Methods: All consecutive patients with a single large HCC treated between 2015 and 2020 in a single tertiary center were reviewed.
Background: Given the scarce donor supply, an increasing number of so-called marginal or extended criteria donor (ECD) organs are used for liver transplantation. These ECD liver grafts are however known to be associated with a higher rate of early allograft dysfunction and primary non-function because of a greater vulnerability to ischemia-reperfusion injury. The end-ischemic hypothermic oxygenated machine perfusion (HOPE) technique may improve outcomes of liver transplantation with ECD grafts by decreasing reperfusion injury.
View Article and Find Full Text PDFBackground: With a mortality rate of up to 30%, post-pancreatectomy hemorrhage (PPH) remains a serious complication after pancreatoduodenectomy (PD) for cancer. Little is known about the long-term survival of patients after PPH. This retrospective study aimed to evaluate the impact of PPH on long-term survival after PD.
View Article and Find Full Text PDFBackground: It is unclear whether preoperative biliary drainage (PBD) by endoscopic retrograde cholangiopancreatography (ERCP) is equivalent to electrocautery-enhanced lumen-apposing metal stent (ECE-LAMS) before pancreatoduodenectomy (PD).
Methods: Patients who underwent PBD for distal malignant biliary obstruction (DMBO) followed by PD were retrospectively included in nine expert centers between 2015 and 2022. ERCP or endoscopic ultrasound-guided choledochoduodenostomy with ECE-LAMS were performed.
Background: Factors excluding postoperative pancreatic fistula (POPF), facilitating early drain removal and hospital discharge represent a novel approach in patients undergoing enhanced recovery after pancreatic surgery. This study aimed to establish the relevance of neutrophil-to-lymphocyte ratio (NLR) in excluding POPF after pancreatoduodenectomy (PD).
Methods: A prospectively maintained database of patients who underwent PD at two high-volume centres was used.
Background: In the current setting of organ shortage, brain-dead liver donors with recent liver trauma (RLT) represent a potential pool of donors. Yet, data on feasibility and safety of liver transplantation (LT) using grafts with RLT are lacking.
Methods: All liver grafts from brain-dead donors with RLT proposed for LT between 2010 and 2018 were identified from the nationwide CRISTAL registry of the Biomedicine Agency.
: to date, long-term outcomes of R1 vascular (R1vasc) and R1 parenchymal (R1par) resections in the setting of intrahepatic cholangiocarcinoma (iCCA) have been examined in only one study which did not find significant difference. : we analyzed consecutive patients who underwent iCCA resection between 2000 and 2019 in two tertiary French medical centers. We report overall survival (OS) and disease-free-survival (DFS).
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- - The study investigates the need for therapeutic drug monitoring of tacrolimus (TAC) in organ transplant patients due to its narrow therapeutic index and variability in blood concentrations.
- - The research focuses on the impact of genetic variants and the expression of four drug transporters on TAC concentrations, finding that some transporters correlate with TAC levels in liver and kidney transplant recipients.
- - In vitro experiments confirmed TAC as a substrate of the drug transporter P-glycoprotein (P-gp), while results for other transporters were inconclusive, enhancing our understanding of TAC transport mechanisms in T lymphocytes.
Article Synopsis
- Researchers wanted to find out how to tell if a redo liver transplant (redo-LT) is successful or not, especially since there aren't many organs available to transplant.
- They looked at data from 22 hospitals from 2010 to 2018, focusing on certain patients who had a better chance of having a good outcome after the surgery.
- They found that while most patients had a high survival rate after 1 year, those who had redo-LT for specific complications did not do as well, showing that some cases are riskier than others.
Objective: The aim of the study was to evaluate the impact of the use of a reinforced stapler (RS) during distal pancreatectomy (DP) on postoperative outcomes.
Background: DP remains associated with significant postoperative morbidity owing to pancreatic fistula (PF). To date, there is no consensus on the management of the pancreatic stump.
Background: Bacteriobilia may increase the rate of deep infectious complications (DIC) after pancreaticoduodenectomy. To better adjust prophylactic and empirical antibacterial treatment, we aimed to characterize bacteriobilia in patients with preoperative endoprosthesis, and its association with postoperative DIC.
Methods: All patients who underwent pancreaticoduodenectomy in our center between 2010 and 2019 were included.
Objective: Defining robust and standardized outcome references for distal pancreatectomy (DP) by using Benchmark analysis.
Background: Outcomes after DP are recorded in medium or small-sized studies without standardized analysis. Therefore, the best results remain uncertain.
How the side of an extended liver resection impacts the postoperative prognosis of advanced perihilar cholangiocarcinoma (PHC) is still controversial. We compared the outcomes of right (RTS) and left trisectionectomies (LTS) in Bismuth-Corlette (BC) type IV PHC resection. All patients undergoing RTS or LTS for BC type IV PHC in a single tertiary center between January 2012 and December 2019 were compared retrospectively.
View Article and Find Full Text PDFIn situ normothermic regional perfusion (NRP) and ex situ normothermic machine perfusion (NMP) aim to improve the outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have not yet been compared directly. In this international observational study, outcomes of LT performed between 2015 and 2019 for organs procured from cDCD donors subjected to NRP or NMP commenced at the donor center were compared using propensity score matching (PSM).
View Article and Find Full Text PDFBackground: Selection of liver grafts suitable for transplantation (LT) mainly depends on a surgeon's subjective assessment. This study aimed to investigate the role of radiomic analysis of donor-liver CTs after brain death (DBD) to predict the occurrence of early posttransplant allograft dysfunction (EAD).
Methods: We retrospectively extracted and analyzed the left lobe radiomic features from CT scans of DBD livers in training and validation cohorts.
Uterine transplantation is on the rise worldwide. In contrast to its arterial anatomy, venous drainage of the uterus is poorly defined in the literature. Our aim was to provide a standardized description of uterine veins through a multimodal approach to establish anatomical landmarks for the uterine transplantation surgeon.
View Article and Find Full Text PDFBackground: The ABO blood group system may influence tumorigenesis, but its prognostic value in liver transplantation (LT) for hepatocellular carcinoma (HCC) has never been assessed.
Methods: All consecutive patients who underwent LT for HCC between 2013 and 2017 at 9 centers were analyzed. Predictors of tumor recurrence were identified using multivariable analysis, while comparison between group A and non-A recipients was performed after propensity score matching.