Publications by authors named "Fabiano Svolacchia"
: The facial skin defects associated with aging are common concerns in the aging population. Hyaluronic-acid-based intradermal gels have established themselves as safe and effective treatments for addressing these concerns. Recently developed enriched products aim to enhance the efficacy of these gels, yet their effectiveness lacks thorough validation in the existing literature.
View Article and Find Full Text PDF: This three-year clinical trial aimed to demonstrate that only the signaling vesicles produced by ADSCa, containing mRNA, microRNA, growth factors (GFs), and bioactive peptides, provide an advantage over classical therapy with adipose disaggregate to make the tissue regeneration technique safer due to the absence of interfering materials and cells, while being extremely minimally invasive. The infiltration of disaggregated adipose nanofat, defined by the Tonnard method, for the regeneration of the dermis and epidermis during physiological or pathological aging continues to be successfully used for the presence of numerous adult stem cells in suspension (ADSCa). An improvement in this method is the exclusion of fibrous shots and cellular debris from the nanofat to avoid inflammatory phenomena by microfiltration.
View Article and Find Full Text PDFArticle Synopsis
- - Migraines, affecting over a billion people globally, are a serious and often misunderstood condition that significantly hampers daily life, leading to social, emotional, and work-related challenges for sufferers and their families.
- - Characterized by debilitating head pain accompanied by nausea, sensitivity to light and sound, migraines can be triggered by various factors, and their complexity requires targeted treatment strategies to alleviate symptoms.
- - The review discusses important aspects of migraine treatment, including the role of CGRP in its pathogenesis, effective drugs like CGRP receptor antagonists, and the potential benefits of dietary interventions like the ketogenic diet in reducing attack frequency.
Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vessel regeneration, muscle regeneration, and fibrous tissue regeneration.
View Article and Find Full Text PDFIn this review, we summarize the most used natural products as useful adjuvants in BC by clarifying how these products may play a critical role in the prevention, treatment and progression of this disease. BC is the leading cancer, in terms of incidence, that affects women. The epidemiology and pathophysiology of BC were widely reported.
View Article and Find Full Text PDFThe aim of this clinical study was to demonstrate that through a micrograft of viable adipose tissue cells microfiltered at 50 microns to exclude fibrous shoots and cell debris in a suspension of cross-linked hyaluronic acid, we were able to improve visible imperfections of the dermis and to improve clinically observable wrinkles, with a beneficial effect also in the extracellular matrix (ECM). : With the passage of time, the aging process begins, resulting in a progressive impairment of tissue homeostasis. The main reason for the formation of wrinkles is the involution of the papillary dermis, as well as the loss of stem cell niches with compromise of the extra-cytoplasmic matrix (ECM), and the loss of hyaluronic acid, which helps to maintain the shape and resistance and that is contained in the connective tissue.
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- Some scars from injuries look bad, and doctors have tried different ways to make them better using both surgeries and other treatments.
- This study looks at how well using a special treatment called dermal autologous micrografts can help improve these ugly scars, especially from burns or accidents.
- The results showed that after 4 months, the scars looked and felt much better, and the scientists found that these micrografts helped fix the skin layers and organized collagen, but they want to do more studies to make sure this method really works well.
Background: The reduction of mortality worldwide has led older individuals to seek intervention modalities to improve their appearance and reverse signs of aging.
Objective: We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin.
Methods: Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture.