Publications by authors named "Fabiana Vieira Mello"
Sphingosine 1-phosphate protective effect on human proximal tubule cells submitted to an in vitro ischemia model: the role of JAK2/STAT3.
J Physiol Biochem
November 2024
Article Synopsis
- * Understanding the underlying mechanisms of AKI is crucial for developing effective treatments, particularly focusing on cell rescue and paracrine factors that aid in tissue repair.
- * In this study, sphingosine 1-phosphate (S1P) was found to significantly enhance cell survival and proliferation in kidney proximal tubule cells after I/R injury, demonstrating its potential in promoting tissue repair via specific signaling pathways, including the SAFE and JAK2/STAT3 pathways.
Diagnostic criteria for juvenile myelomonocytic leukemia (JMML) are currently well defined, however in some patients diagnosis still remains a challenge. Flow cytometry is a well established tool for diagnosis and follow-up of hematological malignancies, nevertheless it is not routinely used for JMML diagnosis. Herewith, we characterized the CD34+ hematopoietic precursor cells collected from 31 children with JMML using a combination of standardized EuroFlow antibody panels to assess the ability to discriminate JMML cells from normal/reactive bone marrow cell as controls (n=29) or from cells of children with other hematological diseases mimicking JMML (n=9).
View Article and Find Full Text PDFFlowcytometric analysis allows for detailed identification and characterization of large numbers of cells in blood, bone marrow, and other body fluids and tissue samples and therefore contributes to the diagnostics of hematological malignancies. Novel data analysis tools allow for multidimensional analysis and comparison of patient samples with reference databases of normal, reactive, and/or leukemia/lymphoma patient samples. Building such reference databases requires strict quality assessment (QA) procedures.
View Article and Find Full Text PDFAcute megakaryoblastic leukemia (AMKL) is a rare and heterogeneous subtype of acute myeloid leukemia (AML). We evaluated the immunophenotypic profile of 72 AMKL and 114 non-AMKL AML patients using the EuroFlow AML panel. Univariate and multivariate/multidimensional analyses were performed to identify most relevant markers contributing to the diagnosis of AMKL.
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