Publications by authors named "Fabiana Perrechil"

Background: COVID-19 is caused by the SARS-CoV-2 virus, an emerging respiratory pathogen. The work environment represents a high-risk factor for health professionals. Given the scarcity of protective personal equipment due to global demand, decontamination and reuse studies should be carried out.

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Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character.

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Article Synopsis
  • Gellan microgels were created using gellan gum and hardening agents like CaCl2 or KCl, with some coated in chitosan for enhanced gastric resistance.
  • The size of the microgels ranged from 70-120 μm and they mostly remained stable in water, except for the uncoated gellan/K type.
  • During digestion tests, all microgels retained their size in the stomach phase, but disintegrated in the intestinal phase, suggesting they're useful for targeted delivery in the digestive system, with chitosan-coated versions showing better stability.
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