Publications by authors named "Fabiana H M de Melo"
Article Synopsis
- Researchers examined the expression of 580 miRNAs in both non-metastatic and metastatic melanoma cells, finding that higher levels of miR-138-5p were linked to increased malignancy.
- Functional experiments demonstrated that miR-138-5p promotes an aggressive cancer phenotype by enhancing cell proliferation, migration, and resistance to cell death, while directly targeting the tumor suppressor Trp53, which is associated with poor prognosis in melanoma cases.
Increased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. fruit pulp in rats in vivo is not related to the direct activation of endothelial cells.
Victória Caroline Bottino Pontes Juliana Pereira Tavares de Melo Tavares Tatiana Rosado Rosenstock Domingos Sávio Rodrigues Marcelo Icimoto Yudi Fabiana Henriques Machado de Melo
J Ethnopharmacol
May 2021
Article Synopsis
- Research shows that the açaí fruit (Euterpe oleracea Mart.) has antioxidant, anti-inflammatory, and anti-lipidemic properties, contributing to lower cardiovascular risks.
- The study aims to assess how a viscous extract from açaí pulp affects blood flow in rats and to understand the underlying mechanisms in rat endothelial cells.
- Results indicate that while the açaí extract increases blood flow through nitric oxide production, its vasodilating effects are not directly due to activation of endothelial cells.
Article Synopsis
- - Cancers often develop through a series of mutations, with some tumors progressing from benign to malignant, leading to the creation of preventive screening programs for at-risk individuals.
- - For those at higher risk of developing cancer, chemoprevention aims to use natural or synthetic compounds to inhibit cancer progression through mechanisms like reducing inflammation and activating protective enzymes.
- - The review highlights various compounds with potential chemopreventive properties, such as sulforaphane and green tea extracts, while also addressing challenges in applying these findings clinically, including issues like toxicity, cost, and patient adherence.
Article Synopsis
- Tumors have various cell types with different metabolic traits that adapt to available oxygen and nutrients, influencing their progression to metastasis.
- Research showed that metastatic cells (4C11+) have heightened mitochondrial function and increased energy production, linked to processes like glutamine breakdown and fatty acid oxidation.
- These findings suggest that specific metabolic characteristics, particularly involving mitochondrial activity, play a crucial role in the transition from non-tumorigenic to metastatic cell phenotypes.
Correction: Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.
Fernanda Molognoni Fabiana Henriques Machado de Melo Camila Tainah da Silva Miriam Galvonas Jasiulionis
PLoS One
September 2015
Article Synopsis
- The text mentions a correction to an article that can be found using the Digital Object Identifier (DOI) 10.1371/journal.pone.0081937.
- Corrections in academic articles are made to address errors or inaccuracies that may affect the study's findings or conclusions.
- This highlights the importance of accuracy and reliability in academic publishing, as corrections help maintain the integrity of the research.
Article Synopsis
- A model for studying melanoma development was created by exposing non-tumorigenic melanocyte cells to repeated cycles of conditions that hinder their attachment.
- The research found that increased levels of superoxide, a reactive oxygen species, lead to changes in DNA methylation and expression of specific genes, contributing to cell transformation.
- The activation of the Ras/Rac1/ERK signaling pathway was identified as a key factor in this process, indicating that environmental stressors like superoxide might trigger early events in melanoma progression.*
Article Synopsis
- * A new tool combining human galectin-3 with bacterial alkaline phosphatase (gal3/AP) was developed to identify specific glycosylation patterns associated with blood groups and lactosamine derivatives, revealing its dependence on N-linked oligosaccharides.
- * Analysis of galectin-3 ligands in normal and tumor samples showed a loss of expression in carcinomas and highlighted gal3/AP's usefulness in studying tumor microenvironments, with similar yet distinct binding