Design and Synthesis of 2-Nitroimidazole-1,2,3-triazole Sulfonamide Hybrids as Potent and Selective Anti-Trypanosomatid Agents.

A series of 2-nitroimidazole-1,2,3-triazole sulfonamide hybrid analogs were designed using medicinal chemistry approaches, such as bioisosterism, molecular hybridization, Topliss tree decision, and Craig plot. A total of 24 compounds were synthesized via click chemistry in satisfactory yields. Overall, analogs 15 a-x exhibited relevant in vitro anti-trypanosomatid activity against amastigote forms of T.

Control of Biofilms by an Ethanolic Extract of (Schrank) Pilger Leaves.

is an etiologic agent of cryptococcosis and a serious disease that affects immunocompromised and immunocompetent patients worldwide. The therapeutic arsenal used to treat cryptococcosis is limited to a few antifungal agents, and the ability of to form biofilms may hinder treatment and decrease its susceptibility to antifungal agents. The objective of this study was to evaluate the antifungal and antibiofilm activities of an ethanolic extract of (Schrank) Pilger leaves against .