Publications by authors named "Fabiana Evaristo Mendonca"
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are dynamic cells that can sense the environment, adapting their regulatory functions to different conditions. Accordingly, the therapeutic potential of BM-MSCs can be modulated by preconditioning strategies aimed at modifying their paracrine action. Although rat BM-MSCs (rBM-MSCs) have been widely tested in preclinical research, most preconditioning studies have employed human and mouse BM-MSCs.
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- Gabapentin (GBP) is an anti-convulsive drug shown to effectively reduce neuropathic pain in Wistar rats through oral treatment before and after chronic nerve injury.
- GBP at a dosage of 60 mg/kg significantly decreased pain behaviors and increased motor activity in the subjects compared to those receiving saline, indicating a positive impact on pain management.
- Additionally, GBP treatment enhanced myelin basic protein expression and improved nerve morphology, suggesting it promotes nerve remyelination following sciatic nerve damage.