Zinc and aging: a narrative review of the effects on hematopoiesis and its link with diseases.

There has been a global increase in the older population in recent decades and, as age advances, complex metabolic and epigenetic changes occur in the organism, and these may trigger some health complications commonly found among this population. Additionally, several changes occur in older people that can reduce the dietary intake or the process of nutrient absorption. In this way, tissues with high nutrient requirements are more affected.

A review of the role of zinc finger proteins on hematopoiesis.

The bone marrow is responsible for producing an incredible number of cells daily in order to maintain blood homeostasis through a process called hematopoiesis. Hematopoiesis is a greatly demanding process and one entirely dependent on complex interactions between the hematopoietic stem cell (HSC) and its surrounding microenvironment. Zinc (Zn) is considered an important trace element, playing diverse roles in different tissues and cell types, and zinc finger proteins (ZNF) are proteins that use Zn as a structural cofactor.

Poly(butylene adipate-co-terephthalate)/Poly(lactic acid) Polymeric Blends Electrospun with TiO-R/FeO for Pollutant Photodegradation.

This work aimed to use the electrospinning technique to obtain PBAT/PLA polymer fibers, with the semiconductors rutile titanium dioxide (TiO-R) and magnetite iron oxide (FeO), in order to promote the photocatalytic degradation of environmental contaminants. The parameters used in the electrospinning process to obtain the fibers were distance from the needle to the collecting target of 12 cm, flow of 1 mL h and voltage of 14 kV. The best mass ratio of semiconductors in the polymeric fiber was defined from a 2 experimental design, and the values obtained were 10% TiO-R, 1% FeO at pH 7.

Dietary magnesium restriction affects hematopoiesis and triggers neutrophilia by increasing STAT-3 expression and G-CSF production.

Background & Aims: Magnesium (Mg) is able to modulate the differentiation and proliferation of cells. Mg restriction can trigger neutrophilia, but the processes that result in this change have yet to be investigated and are not fully understood. Hematopoiesis is a complex process that is regulated by many factors, including cytokines and growth factors, and is strongly influenced by nutrient availability.

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis.

Magnesium (Mg) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells.

Sugarcane biomass colonized by for red 4B dye removal: a sustainable alternative.

Biosorption of the red 4B dye was evaluated using non-colonized sugarcane bagasse and colonized by . The fungal colonization caused an increase in the acid and phenolic groups, making the biosorbent surface more positive, with lower thermal stability due to decomposition of lignocellulosic compounds, lower pHpcz, and smaller pores. The biosorbents showed better adsorption at pH 2.

An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells.

Magnesium (Mg) is a mineral with the ability to influence cell proliferation and to modulate inflammatory/immune responses, due to its anti-inflammatory properties. In addition, mesenchymal stem cells (MSCs) modulate the function of all major immune cell populations. Knowing that, the current work aimed to investigate the effects of Mg enrichment, and its influence on the immunomodulatory capacity of MSCs.

Influence of magnesium on insulin resistance in obese women.

The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n = 59) and case (obese women, n = 55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.

Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure.

Protein malnutrition (PM) results in pathological changes that are associated with peripheral leukopenia, bone marrow (BM) hypoplasia and alterations in the BM microenvironment leading to hematopoietic failure; however, the mechanisms involved are poorly understood. In this context, the BM mesenchymal stem cells (MSCs) are cells intimately related to the formation of the BM microenvironment, and their differentiation into adipocytes is important because adipocytes are cells that have the capability to negatively modulate hematopoiesis. Two-month-old male Balb/c mice were subjected to protein-energy malnutrition with a low-protein diet containing 2% protein, whereas control animals were fed a diet containing 12% protein.

Modulation of the nuclear factor-kappa B (NF-κB) signalling pathway by glutamine in peritoneal macrophages of a murine model of protein malnutrition.

Background And Aims: Protein malnutrition affects resistance to infection by impairing the inflammatory response, modifying the function of effector cells, such as macrophages. Recent studies have revealed that glutamine-a non-essential amino acid, which could become conditionally essential in some situations like trauma, infection, post-surgery and sepsis-is able to modulate the synthesis of cytokines. The aim of this study was to evaluate the effect of glutamine on the expression of proteins involved in the nuclear factor-kappa B (NF-κB) signalling pathway of peritoneal macrophages from malnourished mice.