Publications by authors named "Fabiana Covolo de Souza Santana"
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2.
Cien Saude Colet
June 2023
Article Synopsis
- - Brazil experienced a high number of COVID-19 cases and deaths, yet research on infection spread among family members was limited; this study investigates familial transmission in Bauru, São Paulo from July to November 2020.
- - The research involved 974 participants, including 233 index patients and 741 familial contacts, who were tested for COVID-19 using both rapid antigen tests and RT-PCR; validation of rapid tests was performed in a subgroup of 121 individuals.
- - Results revealed that 44.9% of familial contacts (333 cases) tested positive for COVID-19, with findings suggesting that earlier testing of index patients is crucial for controlling transmission among family members.
Despite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by Mycobacterium leprae (M. leprae), and there is a consensus that the most significant genetic association with leprosy is attributed to the major histocompatibility complex (MHC).
View Article and Find Full Text PDFAssociation between NDO-LID and PGL-1 for leprosy and class I and II human leukocyte antigen alleles in an indigenous community in Southwest Amazon.
Braz J Infect Dis
October 2020
The frequencies of the Human leukocyte antigen (HLA) alleles in the Puyanawa indigenous reserve population and their association with the NDO-LID and ELISA PGL-1 rapid serological test was assessed. This was a cross-sectional study with an epidemiological clinical design conducted in two indigenous communities in the state of Acre, Brazil. Blood was collected in a tube with EDTA to identify HLA alleles and perform serological tests.
View Article and Find Full Text PDFBackground: Renal transplant recipients are submitted to immunosuppression to avoid graft rejection, which makes them susceptible to various conditions. Furthermore, these individuals present malignant tumors more frequently than the general population, including nonmelanoma skin cancer. The individual genetic basis that acts in the pathogenesis of cutaneous cancer may present a protection or susceptibility factor for disease development.
View Article and Find Full Text PDFBackground: Evidence suggests that human leukocyte antigen (HLA) alleles influence the host immune response against Mycobacterium leprae. However, the association between HLA alleles and borderline (B) leprosy has not been studied. The aim of this study was to determine whether HLA class I and II molecules are associated with susceptibility or resistance to B leprosy including borderline-tuberculoid (BT), borderline-borderline (BB), and borderline-lepromatous (BL).
View Article and Find Full Text PDFBackground: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy.
Methods: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher's exact test and stepwise multivariate analysis.
Background: HLA allele identification is used in bone marrow transplant programs as HLA compatibility between the donor and recipient may prevent graft rejection.
Objective: This study aimed to estimate the frequency of alleles and haplotypes of the HLA system in the region of Bauru and compare these with the frequencies found in other regions of the country.
Methods: HLA-A*, HLA-B*, and HLA-DRB1* allele frequencies and haplotypes were analyzed in a sample of 3542 volunteer donors at the National Registry of Voluntary Bone Marrow Donors (REDOME) in Bauru.