Publications by authors named "Fabiana C Vilela Giusti"
Sepsis-associated encephalopathy, which manifests in severe cognitive and depressive symptoms, is directly linked to neuroinflammation. Our study investigates the efficacy of 25H-NBOMe, a phenethylamine, in alleviating these symptoms, potentially offering an innovative treatment for post-sepsis depression. Wistar rats, weighing between 250-300 g, were subjected to cecal ligation and puncture (CLP) surgery to induce sepsis.
View Article and Find Full Text PDFGiven the critical role of maternal care in the neurodevelopment of offspring, this study aimed to investigate the effects of the psychedelic substance 25 H-NBOMe on maternal behavior in lactating rats and its subsequent impact on the social and neurodevelopmental behavior of the offspring. We administered two different dosages of 25 H-NBOMe (0.3 mg/kg and 1.
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- * The study investigated the long-term effects of MIA in adult male rats, revealing increased anxiety-like behaviors and altered cardiovascular stress responses through various behavioral tests.
- * Results showed that MIA offspring displayed distinct anxious behaviors, such as reduced interaction in social settings and heightened blood pressure under stress, highlighting the link between maternal health and offspring neurobehavioral outcomes.
Background And Aims: Newborn infants are vulnerable to procedural stress and pain exposure on the first weeks of life that represents a critical period for the development of nociceptive, sensory, emotional, and social functions. We evaluated the nociceptive behavior of adult male and female rats that were submitted to nociceptive experience in the neonatal period and the maternal behavior in the postnatal period.
Methods: The animals were submitted to repetitive needle pricking from the second to the fifteenth postnatal day (PND 2-15).