Publications by authors named "Fabian Tuebing"
Article Synopsis
- The study discovers that the five known proteasomal ubiquitin receptors in yeast are not essential for recognizing ubiquitin, introducing a new receptor, Rpn1.
- The Rpn1 receptor contains a specific site (T1) that binds to ubiquitin and ubiquitin-like domains, with a preference for lysine 48-linked ubiquitin chains.
- Additionally, there is a second site (T2) on Rpn1 that helps in breaking down ubiquitin chains by interacting with a deubiquitinating enzyme, demonstrating a complex recognition system in the proteasome.
MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified.
View Article and Find Full Text PDFMammalian Staufen2 (Stau2) is a member of the double-stranded RNA-binding protein family. Its expression is largely restricted to the brain. It is thought to play a role in the delivery of RNA to dendrites of polarized neurons.
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