Publications by authors named "Fabian Lang"

Purpose: Bloodstream infections caused by Pseudomonas aeruginosa (PABSI) in hematological patients are associated with high morbidity and mortality. We investigated the epidemiology, risk factors, and outcomes of PABSI at our center.

Methods: All adult hematological patients with PABSI between January 2013 and July 2023 were included.

View Article and Find Full Text PDF

Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare, but prognostically extremely unfavorable and associated with very high mortality rates. Aim of our single-center study was to define risk factors for CNS relapse in patients with FLT3-mutated AML after allogeneic hematopoietic cell transplantation (HCT) and to determine the impact of pre-emptive or salvage therapy with FLT3-inhibitors (FLT3i) on occurrence of CNS relapse and overall prognosis. We analyzed 39 FLT3-mutated AML patients who were treated with intensive induction therapy and consecutively underwent HCT at our institution.

View Article and Find Full Text PDF
Article Synopsis
  • Patients getting stem cell transplants have a high chance of getting infections, especially right after the procedure, but using regular antibiotics can cause other health issues.
  • A study compared a new antibiotic treatment (IAT) with regular antibiotic use (SAP) and found that while IAT led to fewer days on antibiotics, patients had more bloodstream infections.
  • Overall, both treatments had similar long-term survival rates and health outcomes, suggesting that IAT could be a safe alternative to SAP for these patients.
View Article and Find Full Text PDF

Background And Aims: Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndromes (ACS).

Methods: Proenkephalin was measured in plasma in a prospective multicentre ACS cohort from Switzerland (n=4787) and in validation cohorts from the UK (n=1141), Czechia (n=927), and Germany (n=220).

View Article and Find Full Text PDF

Wavelength-shifting molecular beacons were prepared from L-DNA. The clickable anchor for the two dyes, Cy3 and Cy5, was 2'--propargyl-L-uridine and was synthesized from L-ribose. Four clickable molecular beacons were prepared and double-modified with the azide dyes by a combination of click chemistry on a solid support for Cy3 during DNA synthesis and postsynthetic click chemistry for Cy5 in solution.

View Article and Find Full Text PDF
Article Synopsis
  • - Asciminib specifically targets the unique myristoyl pocket of BCR::ABL1, proving effective against chronic myeloid leukemia (CML) that has mutations resistant to other treatments, particularly in heavily pretreated patients.
  • - In a phase I study of 48 patients with the T315I mutation, 62.2% reached a BCR::ABL1 level of ≤1% and nearly 49% achieved a major molecular response, demonstrating significant antileukemic activity over a two-year period.
  • - Common severe side effects included increased lipase and low platelet counts, but the overall risk-benefit profile supports asciminib as a viable treatment for T315I-mutated CML-CP
View Article and Find Full Text PDF

Introduction: Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ALL) is treated as standard of care (SoC) by imatinib-based treatment combined with induction and consolidation chemotherapy followed by allogeneic stem cell transplantation (SCT) in first remission. The German Multicenter ALL Study Group for Adult ALL (GMALL) reports about a trial to evaluate the impact of ponatinib-based therapy, blinatumomab treatment for suboptimal responders, and the possibility of omission of SoC Allo SCT in optimal responders entitled GMALL-EVOLVE.

Methods: Herein, imatinib is randomized versus ponatinib as frontline treatment combined with chemotherapy, optimal responders also get randomized between SCT and chemo-immunotherapy, and suboptimal responders receive immunotherapy before SCT.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates if high-dose cytarabine-based salvage chemotherapy before allogeneic stem-cell transplantation improves survival in patients with acute myeloid leukaemia who haven't responded well to previous treatments.
  • 281 patients aged 18 to 75 were randomly assigned to either receive chemotherapy or immediate stem-cell transplantation; the main goal was to measure treatment success as complete remission by day 56 after HSCT.
  • Results showed that 83% of patients in the chemotherapy group achieved treatment success, suggesting that prior chemotherapy could be an effective approach before transplantation in these patients.
View Article and Find Full Text PDF

Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the mouse germline.

View Article and Find Full Text PDF

We present the case of a 58-year-old female patient who presented with an extramedullary B-ALL relapse after prior allogenic HSCT and blinatumomab therapy. The patient died from complications of a drug-induced acute liver failure after a salvage therapy combining inotuzumab ozogamicin (InO)-based induction followed by consolidation with high dose MTX and pegaspargase based on the GMALL protocol for older ALL patients. After a diagnosis of the extramedullary relapse in the form of a retro vesical chloroma, the patient received an individualized multi-agent chemotherapy based on induction chemotherapy for older patients in combination with InO.

View Article and Find Full Text PDF

The addition of midostaurin to standard chemotherapy has improved survival in patients with FLT3-mutated AML. However, the impact of midostaurin and other FLT3 inhibitors (FLT3i) on cardiovascular adverse events (CAEs) has not been studied in patients who underwent allogeneic hematopoietic stem cell transplantation in a real-world setting. We reviewed 132 patients with AML who were treated with intensive induction therapy and consecutive allogeneic stem cell transplantation at our institution (42 FLT3-mutated AML and 90 with FLT3 wildtype).

View Article and Find Full Text PDF

Background: Third-generation chimeric antigen receptor (CAR)-engineered T cells (CARTs) might improve clinical outcome of patients with B cell malignancies. This is the first report on a third-generation CART dose-escalating, phase-1/2 investigator-initiated trial treating adult patients with refractory and/or relapsed (r/r) acute lymphoblastic leukemia (ALL).

Methods: Thirteen patients were treated with escalating doses of CD19-directed CARTs between 1 × 10 and 50 × 10 CARTs/m.

View Article and Find Full Text PDF

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores.

View Article and Find Full Text PDF

The synthesis of enantiomerically pure titanocenes is limited to cases with enantiomerically pure substituents at the cyclopentadienyl ligands and to ansa-titanocenes. For the latter complexes, the use of achiral ligands requires a resolution of enantiomers and frequently also a separation of the diastereoisomers obtained after metalation. Here, we introduce a new synthetic method that relies on the use of enantiomerically pure camphorsulfonate (CSA) ligands as control elements for the absolute and relative configuration of titanocene complexes.

View Article and Find Full Text PDF

Asciminib is approved for patients with Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia (CML-CP) who received ≥2 prior tyrosine kinase inhibitors or have the T315I mutation. We report updated results of a phase 1, open-label, nonrandomized trial (NCT02081378) assessing the safety, tolerability, and antileukemic activity of asciminib monotherapy 10-200 mg once or twice daily in 115 patients with CML-CP without T315I (data cutoff: January 6, 2021). After ≈4-year median exposure, 69.

View Article and Find Full Text PDF

Aminophthalimide and ,-dimethylaminophthalimide are used as fluorescent mimetics of purines due to their similar size and their possibility for hydrogen bonding. Their C-nucleotides were synthetically incorporated into RNA by means of phosphoramidite chemistry, behave as nonspecific fluorescent base analogs with flexible hydrogen bonding capabilities, and show solvatochromic fluorescence that is suitable for RNA imaging in live cells.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines how early life stress (ELS), education, and symptom severity impact cognitive performance in patients with schizophrenia and healthy controls.* -
  • Findings show that ELS negatively affects cognitive ability, with a stronger association seen in healthy controls compared to schizophrenia patients.* -
  • The results suggest that cognitive deficits are influenced by both symptom burden in patients and educational background, indicating that schizophrenia symptoms can obscure the effects of early life stress on cognition.*
View Article and Find Full Text PDF

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores.

View Article and Find Full Text PDF

Background: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance.

View Article and Find Full Text PDF

Background And Hypothesis: Meta-analyses have shown that the majority of patients with schizophrenia who have not improved after 2 weeks of treatment with an antipsychotic drug are unlikely to fully respond later. We hypothesized that switching to another antipsychotic with a different receptor binding profile is an effective strategy in such a situation.

Study Design: In total, 327 inpatients with an acute exacerbation of schizophrenia were randomized to double-blind treatment with either olanzapine (5-20 mg/day) or amisulpride (200-800 mg/day).

View Article and Find Full Text PDF

Introduction: According to the World Health Organization, medication adherence is defined as the extent to which a person's behavior corresponds with an agreed recommendation from a healthcare provider. Approximately 50% of patients do not take their medication as prescribed, and non-adherence can contribute to the progress of a disease. For patients suffering from mental diseases non-adherence plays an important role.

View Article and Find Full Text PDF
Article Synopsis
  • Early detection of psychosis symptoms could lead to better health outcomes, and understanding genetic susceptibility using polygenic risk scores (PRSs) can assist in early intervention strategies.
  • The study computed PRSs for schizophrenia and bipolar disorder using advanced statistical methods and analyzed data from diverse clinical and healthy groups to assess the scores' effectiveness in predicting mental health conditions.
  • Significant differences in genetic risk scores were found between control and at-risk or clinical groups, supporting the notion of a continuum of psychosis symptoms that require further clinical attention and research for better diagnostic accuracy.
View Article and Find Full Text PDF