Publications by authors named "Fabian Hustadt"
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[F]fluoro-L-m-tyrosine imaging and motor performances analysis.
Neurobiol Aging
November 2021
Article Synopsis
- - The study developed a rat model (A53T-AAV) to analyze the progression of Parkinson's disease by tracking motor function and dopaminergic deficits over 12 weeks.
- - Researchers used the [F]FMT Positron Emission Tomography (PET) radiotracer to monitor changes, noting increased phosphorylated α-synuclein and a decrease in dopaminergic function.
- - The findings showed that reductions in [F]FMT PET signals correlated with observed motor dysfunction, establishing a reliable model for tracking alpha-synuclein pathology in relation to behavioral impairments.
In multiple sclerosis patients, demyelination is prominent in both the white and gray matter. Chronic clinical deficits are known to result from acute or chronic injury to the myelin sheath and inadequate remyelination. The underlying molecular mechanisms of remyelination and its failure remain currently unclear.
View Article and Find Full Text PDFBecause of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson's disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the preclinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [ F]fluoro-3,4-dihydroxyphenyl-L-alanine ([ F]FDOPA) and 6-[ F]fluoro-L-m-tyrosine ([ F]FMT).
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