Publications by authors named "Fabian Alperth"
Article Synopsis
- The study explores the use of natural deep eutectic solvents (NADES) for extracting spilanthol, a compound from flower heads, highlighting a shift toward greener chemistry practices.
- Twenty choline chloride-based NADES were tested against ethanol, revealing that a specific combination of choline chloride and 1,2-propanediol with some water yielded spilanthol efficiently, comparable to ethanol's performance.
- Results indicate that while extraction temperature impacts yield positively, adding too much water reduces effectiveness, suggesting NADES may offer a non-toxic alternative for medicinal extractions.
Article Synopsis
- * NMR analysis, utilizing pyridine-d for improved resolution of B-ring signals, helped correct the structural assignments of three related compounds through 2D NMR experiments.
- * LC-PDA-ESI-MS with a specialized PFP stationary phase confirmed the NMR findings and analyzed several extracts to detect the presence of the identified compounds, showcasing distinct mass spectral features through fragmentation.
The heartwood of the Swiss Stone Pine, L., has been scarcely investigated for secondary metabolites for a long period of time. Considering age and relative simplicity of heartwood investigations dating back to the 1940s to 1960s, we conducted the first investigation of heartwood by HPLC, using UHPLC-DAD-ESI-MS and HPLC-DAD techniques in combination with isolation and NMR spectroscopy, with focus on stilbenes, bibenzyls and flavonoids.
View Article and Find Full Text PDFHoutt. is a critical invasive alien plant in Europe and North America with a drastic impact on native flora. However, has medicinal potential, especially as a source of stilbenes.
View Article and Find Full Text PDFEfflux Pump Inhibition and Resistance Modulation in by and Its Coumarins.
Antibiotics (Basel)
September 2021
Antibiotic resistance is a growing problem and may become the next major global health crisis if no timely actions are taken. Mycobacterial infections are widespread and, due to antibiotic resistance, also hard to treat and a major cause of mortality. Natural compounds have the potential to increase antibiotic effectiveness due to their resistance modulatory and antimicrobial effects.
View Article and Find Full Text PDFLittle is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L-1.
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