Improving the suppressive power of homing gene drive by co-targeting a distant-site female fertility gene.

Gene drive technology has the potential to address major biological challenges. Well-studied homing suppression drives have been shown to be highly efficient in Anopheles mosquitoes, but for other organisms, lower rates of drive conversion prevent elimination of the target population. To tackle this issue, we propose a gene drive design that has two targets: a drive homing site where drive conversion takes place, and a distant site where cleavage induces population suppression.

How moral bioenhancement affects perceived praiseworthiness.

Psychological literature indicates that actions performed with the assistance of cognition-enhancing biomedical technologies are often deemed to be less praiseworthy than similar actions performed without such assistance. This study examines (i) whether this result extends to the bioenhancement of moral capacities, and (ii) if so, what explains the effect of moral bioenhancement on perceived praiseworthiness. The findings indicate that actions facilitated by morally bioenhanced individuals are considered less deserving of praise than similar actions facilitated by 'traditional' moral enhancement-for example, moral self-education.

The intersection of race and femininity in the classroom.

This vignette told in eight graphic panels illustrates a story about how emotional responses associated with White femininity are used to derail a classroom discussion about racial injustice in a university setting. The panels show how this weaponization of femininity occurs and how it shields those who wield it from external criticism while centering themselves in conversations about race. Women of other races typically cannot access this psychological tactic, thus it constitutes a strategic intersectional use of race, psychology, and privilege to access a power position.

Regional management of worsening heart failure: rationale and design of the CHAIN-HF registry.

Aims: Heart failure (HF) is a progressive disease in which periods of clinical stability are interrupted by episodes of clinical deterioration known as worsening heart failure (WHF). Patients who develop WHF are at high risk of subsequent death, rehospitalization, and excessive healthcare costs. As such, WHF could be seen as a separate disease stage and precursor of advanced HF.

Duration of Antibiotic Prophylaxis for Ballistic Fractures to the Extremities.

Background: In the U.S. there are thousands of ballistic firearm injuries to the extremities and subsequent infections, yearly.

The suppressive potential of a gene drive in populations of invasive social wasps is currently limited.

Social insects are very successful invasive species, and the continued increase of global trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its range in Western Europe. As an apex insect predator, this hornet poses a serious threat to the honey bee industry and endemic pollinators.

A Systematic Review of Black People Coping With Racism: Approaches, Analysis, and Empowerment.

This article reviews the current research literature concerning Black people in Western societies to better understand how they regulate their emotions when coping with racism, which coping strategies they use, and which strategies are functional for well-being. A systematic review of the literature was conducted, and 26 studies were identified on the basis of a comprehensive search of multiple databases and reference sections of relevant articles. Studies were quantitative and qualitative, and all articles located were from the United States or Canada.

A neuroscientific perspective on the computational theory of social groups.

We welcome a computational theory on social groups, yet we argue it would benefit from a broader scope. A neuroscientific perspective offers the possibility to disentangle which computations employed in a group context are genuinely social in nature. Concurrently, we emphasize that a unifying theory of social groups needs to additionally consider higher-level processes like motivations and emotions.

Humans first: Why people value animals less than humans.

People routinely give humans moral priority over other animals. Is such moral anthropocentrism based in perceived differences in mental capacity between humans and non-humans or merely because humans favor other members of their own species? We investigated this question in six studies (N = 2217). We found that most participants prioritized humans over animals even when the animals were described as having equal or more advanced mental capacities than the humans.

A gene drive does not spread easily in populations of the honey bee parasite .

Unlabelled: Varroa mites () are the most significant threat to beekeeping worldwide. They are directly or indirectly responsible for millions of colony losses each year. Beekeepers are somewhat able to control varroa populations through the use of physical and chemical treatments.

When Helping Is Risky: The Behavioral and Neurobiological Trade-off of Social and Risk Preferences.

Helping other people can entail risks for the helper. For example, when treating infectious patients, medical volunteers risk their own health. In such situations, decisions to help should depend on the individual's valuation of others' well-being (social preferences) and the degree of personal risk the individual finds acceptable (risk preferences).

Why stress and hunger both increase and decrease prosocial behaviour.

Humans are regularly in suboptimal psychophysiological states like stressed or hungry. Previous research has made both claims that such impairments should decrease and that they should increase prosocial behaviour. We describe the overarching theoretical reasoning underlying these opposing predictions.

Novel combination of CRISPR-based gene drives eliminates resistance and localises spread.

Invasive species are among the major driving forces behind biodiversity loss. Gene drive technology may offer a humane, efficient and cost-effective method of control. For safe and effective deployment it is vital that a gene drive is both self-limiting and can overcome evolutionary resistance.

Tomato Fruit Detection and Counting in Greenhouses Using Deep Learning.

Accurately detecting and counting fruits during plant growth using imaging and computer vision is of importance not only from the point of view of reducing labor intensive manual measurements of phenotypic information, but also because it is a critical step toward automating processes such as harvesting. Deep learning based methods have emerged as the state-of-the-art techniques in many problems in image segmentation and classification, and have a lot of promise in challenging domains such as agriculture, where they can deal with the large variability in data better than classical computer vision methods. This paper reports results on the detection of tomatoes in images taken in a greenhouse, using the MaskRCNN algorithm, which detects objects and also the pixels corresponding to each object.

Utilitarianism for animals, Kantianism for people? Harming animals and humans for the greater good.

Most people hold that it is wrong to sacrifice some humans to save a greater number of humans. Do people also think that it is wrong to sacrifice some animals to save a greater number of animals, or do they answer such questions about harm to animals by engaging in a utilitarian cost-benefit calculation? Across 10 studies ( = 4,662), using hypothetical and real-life sacrificial moral dilemmas, we found that participants considered it more permissible to harm a few animals to save a greater number of animals than to harm a few humans to save a greater number of humans. This was explained by a reduced general aversion to harm animals compared with humans, which was partly driven by participants perceiving animals to suffer less and to have lower cognitive capacity than humans.

The effects of psychosocial stress on intergroup resource allocation.

Stress changes our social behavior. Traditionally, stress has been associated with "fight-or-flight" - the tendency to attack an aggressor, or escape the stressor. But stress may also promote the opposite pattern, i.

The Psychology of Existential Risk: Moral Judgments about Human Extinction.

The 21st century will likely see growing risks of human extinction, but currently, relatively small resources are invested in reducing such existential risks. Using three samples (UK general public, US general public, and UK students; total N = 2,507), we study how laypeople reason about human extinction. We find that people think that human extinction needs to be prevented.

Acute hunger does not always undermine prosociality.

It has been argued that, when they are acutely hungry, people act in self-protective ways by keeping resources to themselves rather than sharing them. In four studies, using experimental, quasi-experimental, and correlational designs (total N = 795), we examine the effects of acute hunger on prosociality in a wide variety of non-interdependent tasks (e.g.

Nudging Immunity: The Case for Vaccinating Children in School and Day Care by Default.

Many parents are hesitant about, or face motivational barriers to, vaccinating their children. In this paper, we propose a type of vaccination policy that could be implemented either in addition to coercive vaccination or as an alternative to it in order to increase paediatric vaccination uptake in a non-coercive way. We propose the use of vaccination nudges that exploit the very same decision biases that often undermine vaccination uptake.

Speciesism, generalized prejudice, and perceptions of prejudiced others.

Philosophers have argued there is a normative relationship between our attitudes towards animals ("speciesism") and other prejudices, and psychological work suggests speciesism relies on similar psychological processes and motivations as those underlying other prejudices. But do laypeople perceive such a connection? We compared perceptions of a target who is high or low on speciesism with those of a target who is high or low on racism (Studies 1-2), sexism (Study 2), or homophobia (Study 3). We find that just like racists, sexists, and homophobes, speciesists were both evaluated more negatively and expected to hold more general prejudicial attitudes and ideologies (e.

Uncertainty about the impact of social decisions increases prosocial behaviour.

Uncertainty about how our choices will affect others infuses social life. Past research suggests uncertainty has a negative effect on prosocial behaviour by enabling people to adopt self-serving narratives about their actions. We show that uncertainty does not always promote selfishness.

Impartiality and infectious disease: Prioritizing individuals versus the collective in antibiotic prescription.

Background: Antimicrobial resistance (AMR) is a global public health disaster driven largely by antibiotic use in human health care. Doctors considering whether to prescribe antibiotics face an ethical conflict between upholding individual patient health and advancing public health aims. Existing literature mainly examines whether patients awaiting consultations desire or expect to receive antibiotic prescriptions, but does not report views of the wider public regarding conditions under which doctors should prescribe antibiotics.

The costs of being consequentialist: Social inference from instrumental harm and impartial beneficence.

Previous work has demonstrated that people are more likely to trust "deontological" agents who reject harming one person to save many others than "consequentialist" agents who endorse such instrumental harms, which could explain the higher prevalence of non-consequentialist moral intuitions. Yet consequentialism involves endorsing not just instrumental harm, but also impartial beneficence, treating the well-being of every individual as equally important. In four studies (total  = 2086), we investigated preferences for consequentialist vs.