Management of late adverse effects after chemoradiation for anal cancer.

Background And Purpose: Significant improvements in the treatment of anal cancer have produced a growing population of anal cancer survivors. These patients often experience late adverse effects related to their treatment. Research has revealed substantial unmet needs because of long-term symptoms and functional impairments after treatment that may negatively affect health-related quality of life.

Long-term anorectal function in rectal cancer patients treated with chemoradiotherapy and endorectal brachytherapy.

Aim: The aim was to study anorectal function in long-term survivors after combined, curatively intended, chemoradiotherapy and endorectal brachytherapy for low rectal cancer.

Methods: This was a case-control design. We compared anorectal function by anal manometry, anal functional lumen imaging probe (EndoFLIP) and rectal bag distension in rectal cancer patients (RCPs) and healthy, normal subjects (NSs).

Cortical processing to anorectal stimuli after rectal resection with and without radiotherapy.

Background: Bowel dysfunction is common after surgery for rectal cancer, especially when neoadjuvant radiotherapy is used. The role of sensory function in the pathogenesis remains obscure, and the aim of the present study was to characterize the sensory pathways of the brain-gut axis in rectal cancer patients treated with resection ± radiotherapy compared with healthy volunteers.

Methods: Sensory evaluation by (neo)rectal distensions was performed and sensory evoked potentials (SEPs) were recorded during rapid balloon distensions of the (neo)rectum and anal canal in resected patients with (n = 8) or without (n = 12) radiotherapy.

Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer.

Introduction: Sphincter-sparing radiotherapy or chemoradiation (RT/CRT) have become the standard treatments for most patients with anal cancer. Unfortunately, long-term survivors often suffer from severe bowel symptoms indicating sensory dysfunction. The aim of the present study was to characterize the sensory pathways of the brain-gut axis after radiotherapy for anal cancer.

Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe.

Background: Sphincter-sparing radiotherapy or chemoradiation are standard treatments for patients with anal cancer. The ultimate treatment goal is full recovery from anal cancer with preserved anorectal function. Unfortunately, long-term survivors often suffer from severe anorectal symptoms.

Ageing with neurogenic bowel dysfunction.

Study Design: Longitudinal study with postal survey.

Objectives: To describe changes in the patterns of neurogenic bowel dysfunction and bowel management in a population of people with spinal cord injury (SCI) followed for two decades.

Setting: Members of the Danish SCI Association.

Chronic abdominal pain in long-term spinal cord injury: a follow-up study.

Study Design: A longitudinal postal survey.

Objectives: To evaluate the prevalence and characteristics of abdominal pain in long-term spinal cord injury (SCI).

Setting: Members of the Danish SCI Association.

Autonomic dysreflexia during bowel evacuation procedures and bladder filling in subjects with spinal cord injury.

Study Design: Randomized, controlled clinical trial.

Objectives: Bladder and bowel management may cause serious autonomic dysreflexia (AD) in subjects with high spinal cord injury (SCI). We aimed at investigating autonomic responses to digital rectal evacuation (DE), transanal irrigation (TAI) with 500 ml and filling cystometry (FC) in SCI.

Abdominal Pain: A Comparison between Neurogenic Bowel Dysfunction and Chronic Idiopathic Constipation.

Introduction. Most spinal-cord-injured patients have constipation. One-third develop chronic abdominal pain 10 years or more after injury.

Do gastrointestinal transit times and colonic dimensions change with time since spinal cord injury?

Study Design: Long-term follow-up study.

Objectives: To determine whether gastrointestinal transit times (GITTs) and colonic dimensions change during the first or subsequent decades after spinal cord injury (SCI).

Setting: Aarhus University Hospital, Denmark.

Anorectal function after long-term transanal colonic irrigation.

Aim: The increased use of transanal colonic irrigation (TAI) warrants study of its effects on anorectal function after long term use.

Method: Anorectal physiology tests were performed in 12 patients with chronic idiopathic constipation (CC) and 10 with idiopathic faecal incontinence (FI) [median 55 years (range 21-70)] before and after a median 68 (range 32-113) months use of TAI.

Results: In CC median, urge rectal volume increased from 121 (70-264) to 268 ml (69-484) (P = 0.

Long-term outcome and safety of transanal colonic irrigation for neurogenic bowel dysfunction.

Study Design: Long-term follow-up study.

Objectives: Short-term results find transanal colonic irrigation (TAI) favourable in the treatment of neurogenic bowel dysfunction (NBD). Therefore, long-term results need to be described.

The pattern of colorectal dysfunction changes with time since spinal cord injury.

Background: Cross-sectional studies suggest that colorectal dysfunction after spinal cord injuries (SCI) worsens as time goes by. However, follow-up studies are needed to prove this.

Study Design: Prospective study.

Abdominal pain in long-term spinal cord injury.

Objectives: To describe the prevalence and character of chronic abdominal pain in a group of patients with long-term spinal cord injury (SCI) and to assess predictors of abdominal pain.

Study Design: Postal survey.

Setting: Members of the Danish Paraplegic Association.