Publications by authors named "Fa-zheng Shen"
Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, recently identified as a target gene of c‑Myc and is frequently dysregulated in multiple cancers. However, to the best of our knowledge, no studies to date have been carried out to investigate the functions of CDCA7L in glioma. Thus, in this study, the expression level of CDCA7L and its association with the prognosis in glioma were detected through the TCGA database.
View Article and Find Full Text PDFBackground: In multiple cancers, long non-coding RNA small nucleolar RNA host gene 20 () is generally dysregulated. In the present study, both the biological role and clinicopathological value of in glioma are explored.
Methods: Real-time PCR was employed to determine expression in glioma patients.
Article Synopsis
- CDCA7L, a member of the JPO protein family and a target gene of c-Myc, is often dysregulated in various cancers, and this study investigates its role and clinical significance in glioma.
- Analysis revealed that higher CDCA7L expression correlates with larger tumor size, higher WHO grade, recurrence, and worse overall and recurrence-free survival rates in glioma patients.
- Knocking down CDCA7L in glioma cells reduced their invasion capabilities, indicating that CDCA7L not only predicts poor prognosis but also contributes to glioma progression, potentially serving as a prognostic biomarker.
Objective: To evaluate the short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and to observe the safety.
Methods: A total of 120 elderly patients with trigeminal nerve tumor were divided into a treatment group and a control group by random draw (n=60), and both groups were subjected to resection by stereotactic image-guided endoscopic nasal surgery. Afterwards, the control group was administered with high-dose cytarabine while the treatment group was given low-dose cytarabine for 14 days.
[Act of Arc siRNA via lentivirus on the memory consolidation of amygdala-kindled rats].
Zhonghua Yi Xue Za Zhi
March 2013
Objective: To explore the memory consolidation related role of gene Arc in amygdala-kindled rats.
Methods: A total of 60 male amygdala-kindled rats were divided equally into 3 groups: 0.9% sodium chloride injection, null vector lentivirus injection and silencing lentivirus injection.
Objective: To explore the effects of low-frequency electric stimulus (LFS) on hippocampal of α5 subunit of extrasynaptic GABAA receptor in kainic acid-induced epilepsy rats and explore the possible mechanism of LFS on hippocampus to treat epilepsy.
Methods: A total of 32 male Sprague-Dawley rats were divided randomly into 4 groups:epileptic, pseudo-surgery, LFS treatment and control. The expression of α5 subunit of extrasynaptic GABAA receptor and the association with the curative effects of LFS were evaluated by behavioristics, real-time fluorogenic quantitative polymerase chain reaction (PCR) and Western blot.
[Expression of α(5) subunit of extrasynaptic GABA(A) receptor in insular-kindled rats].
Zhonghua Yi Xue Za Zhi
July 2012
Objective: To explore the expression of α(5) subunit of extrasynaptic GABA(A) receptor in insular electrical kindled rats and analyze its significance.
Methods: A total of 96 male Sprague-Dawley rats were divided randomly into kindled, sham-operated and control groups (n = 32). And each group was further divided into 2 sub-groups at different time points.